Univase Forte Proteolytic Enzyme Formula


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800 count for

20% more powerful than Wobenzyme, Univase Forte Proteolytic Enzyme formula contains a mixture of 10 different enzymes as well as other synergistic nutrients to enhance the nutritional benefits of this powerful blend of enzymes.† †Results may vary. Ships fresh from manufacturer. FREE SHIPPING – Continental USA only.

200 Count

400 Count

800 Count

Univase Forte Proteolytic Enzyme Formula

 Supports the Body's Natural Inflammation Response

High Alpha-Chymotrypsin | Trypsin Formulation
No One Makes an Enzyme with as much a-Chymotrypsin

NEW & IMPROVED FORMULA | pH Sensitive Enteric Coated Capsules


Volumes have been written about the benefits of pancreatic and plant source proteolytic enzyme formulas. Nutritional physicians for years have used proteolytic enzymes.

NO ONE makes an enzyme with as much as α-chymotrypsin (an extremely potent and long-lived proteolytic enzyme) as is in Univase Forte Proteolytic Enzyme Formula. Compare our ingredients to other so-called “high-potency” enzyme formulations and big name European-made enzymes then compare prices. And now we’ve added Natto-Kinase to make this formulation simply unbeatable.

Univase Forte proteolytic enzyme formula contains a mixture of several different enzymes as well as other synergistic nutrients to enhance the nutritional benefits of this powerful blend of enzymes. It used to be that this product would be best delivered in tablet form. Since stomach acid is highly destructive to pancreatic enzymes and to most plant source enzymes and since capsules are quickly broken down in the stomach, the use of old-style capsules with enzymes is a bad idea. But advances in technology have changed that. Now gelatin capsules can be effectively enteric coated, just like tablets (veggie capsules coming soon!).

For most nutrients, passing through the stomach does no harm and in some cases is helpful and even necessary, but it is not good for most enzymes. Since capsules in the past could not be enteric coated, any enzyme formula in a capsule form was formerly likely to be of a greatly diminished value. Beware of the term “enteric coated.”

An enteric coating is one that is placed over a tablet or capsule to protect its contents. However, unless it indicates the wording ”pH sensitive” before enteric coating, you may be getting a simple protein or even vegetable shellac coating. Protein coatings do work to a limited degree, but can be digested by stomach acid, thus exposing enzymes to premature destruction. Sometimes, the protein coat survives the stomach, and unfortunately the duodenum as well, allowing the tablet to pass through the system undigested.

What is α-Chymotrypsin?

α-Chymotrypsin is an extremely potent pancreatic enzyme of which much has been written. Its activity is so great that most enzyme formulas (including the big name European-made ones) on the market only contain 1/2 to 1 milligram. Univase Forte™* proteolytic enzyme formula contains 60 milligrams (12,000 units) of α-chymotrypsin per capsule. We also have also added the very potent Natto-Kinase 20 mg (400 units) and 1850 mg of Pancreatin. See our technical sheet How to Read an Enzyme Label

Benefits of Using Enzymes

Supports healthy blood. It is a known fact that fungal forms, parasites and bacteria are made up of protein. Viruses also have a protein coating as a shell that protect them. The enzyme protease breaks down proteins, and since the invaders of our blood system are protein, it makes sense that ingesting protease could break down the protein invaders.

Supports a healthy immune system. Enzymes have been found to deliver nutrients to our cells, carry away toxic debris, digest our food, purify our blood, deliver hormones by feeding and fortifying our endocrine system and balance our cholesterol and triglycerides levels while doing no harm to our body.

Breaks down fats. Research has shown that the enzyme lipase breaks down and digests fat. This takes stress off our gallbladder, liver and pancreas. This also supports a healthy weight.

Enzymes support healthy cholesterol and triglycerides levels. Cholesterol and triglycerides are fats that circulate in our blood stream. The enzyme lipase controls the release of these fats which could offer protection from certain forms of heart disease, like atherosclerosis.

Enzymes support healthy mental capacity. Our body uses glucose called from the liver to feed and fortify the hypothalamus. Glucose is made from the protein stored in our liver. Most all plant foods contain protein enzymes. Our red blood cells carry oxygen to the brain and along with glucose to feed the brain cells. When there is a dysfunction with this mechanism we become fatigued and are unable to think clearly. The hypothalamus directs our endocrine system and is responsible for our water balance, body temperature, appetite and emotions.

Enzymes support a healthy colon. Foods that are not digested properly are stored in the colon which can foster the beginning of digestive concerns. Some researchers estimate that nearly 70% of all illness starts in our colon. Undigested protein putrefies, carbohydrates ferment, and fats turn rancid in our colon. Enzymes properly break down food and can help keep the colon free of these toxins. Many researchers suggest having two bowel movements per day supports a healthy elimination system.

Enzymes support healthy sleep. Enzymes enhance the endocrine system. An under nourished endocrine system may create an imbalance in hormones which can negatively affect our nervous system and sleep patterns. When we are unable to digest our food properly or deliver the nutrients to keep our endocrine and nervous system in balance, it becomes difficult to have healthy sleep patterns which then can have an effect on our sleep patterns. It is during sleep that our body does the most repair and cleansing work.

Enzymes help support health weight. Many overweight people have a metabolic imbalance or will soon create one. Remember, the endocrine system regulates metabolism. Once we are able to fortify the endocrine system, have our bowels working regularly and can properly digest food rather than turning it into fat, we have a healthy combination. Enzymes, especially lipase, will break down our fats properly, which will help us burn fat, thus promoting a healthy weight.

Supports healthy aging of skin. An adequate supply of enzymes is absolutely essential for keeping the skin young-looking and healthy. Enzymes support the natural aging process by increasing blood supply to the skin, bringing with it life-giving nutrients and carrying away waste products that can make your skin look dull and wrinkled. Circulation slows down as we get older and enzymes may help support healthy circulation. Replacing digestive enzymes that are lost to the aging process may also help restore optimal nutritional status and alleviate numerous health complaints.

Supports proper pH balance our Gl-tract. Friendly flora such as L. Acidophilus and bifidobacerium are important to the intestinal tract for maintaining proper pH and also for controlling the population of potential pathogenic organisms like clostridium and Candida. Plant flora enzymes have now been proven to be very effective in the pathogen control role of beneficial bacteria. Another role of beneficial bacteria is the actual synthesis of highly favorable natural chemicals in the colon through the fermentation process. These fermented products include such molecular species as natural antibiotics and very importantly, digestive enzymes. These enzymes can play an extremely important role in the digestion of otherwise incompletely digested food substances, especially proteins.

Support proper pH balance in the urine. Research has shown that a balance of the plant enzymes (lipase, protease, and amylase) eaten by individuals produce a proper urine pH of 6.3 to 6.6 in 24 hour urinalysis.


†Results may vary.

Serving Size: 3 capsule
Servings per container: 200, 400, 800 (depending upon bottle size)

Each pH Sensitive Enteric Coated
Capsule Supplies



5,550 mg


450 mg (198,000 FCC U)


450 mg (36 GDU)


2880 mg (216,000 USP U)


180 mg (36,000 USP U)


60 mg (1,200 FU)


50 mg (900 FIP U)


150 mg (1575 U)

Calf Thymus

165 mg

Super-Oxide Dismutase

30 mg (240 IU)


24 mg (240 BU)


30 mg


30 mg

*Capsules have been PH sensitive-coated to insure duodenal assimilation. Other Ingredients: Gelatin, maltodextrin (starch - natural flow agent), medium chain triglycerides
NOTE that we are now reporting total units per single capsule in order to make it easier for our customers to compare with competitive products.


As a dietary supplement: take 1-3 capsules three to four times daily between meals or as directed by your healthcare professional.

CAUTION: If you use the prescription medications acarbose (Precose®) or miglitol (Glyset®), consult your physician before using pancreatin. If you use the medication warfarin (Coumadin®), consult your doctor before using papain (a proteolytic enzyme derived from papaya)


What are Enzymes?

An over simplified explanation of nutritional enzymes is that they are catalysts. That is they cause other reactions to occur in the body or they aid in certain metabolic processes. A nutritional enzyme (an enzyme found in nutritional supplements or in the body) is actually a very specific type of protein. In the case of protein digesting (proteolytic) enzymes, they are literally proteins that break down other proteins. Any unused ingested enzymes are simply converted into amino acids and utilized by the body in a different way. Amino acids are what the human body converts protein based foods into for nutrition. This is why proteolytic or pancreatic enzymes are some of the safest compounds to ingest even in very large quantities.


Enzymes that are delivered to the duodenum by the pancreas during the digestive process would be our own naturally produced pancreatic enzymes or a nutritional supplement containing pancreatic enzymes derived from animal pancreas. The most common pancreatic enzymes are: Pancreatin, Trypsin, Alpha Chymotrypsin (also known as a-chymotrypsin), Lipase, and Amylase. There are others, but these are the most common. The enzymes Trypsin and a-Chymotrypsin are potent protein digesting enzymes. The enzyme Amylase digests starch, and the enzyme Lipase digests fat. The enzyme Pancreatin is not really a specific enzyme, but is actually an enzyme slurry that contains all of the previously mentioned pancreatic enzymes.


There is actually no such enzyme as "protease". Protease merely refers to ANY enzyme that digests protein. The category of protease can include any of the protein digesting pancreatic enzymes as well as any of the protein digesting vegetable, fruit, or other based enzymes. Some enzyme formulas display their contents in a "proprietary blend" of protease that displays an impressive list of enzymes containing trypsin, chymotrypsin and other potent pancreatic enzymes as well a number of vegetable enzymes like Bromelain and  Papain. Quite often the term "proprietary blend" is just a smoke screen to hide the fact that some are using very small amounts of highly active enzymes and large amounts of lesser active enzymes. The concern here is that you just don't know how much of each enzyme is in the Proprietary blend. A "proprietary blend" only tells you what enzymes are in the blend and conceals the actual potencies of the individual enzymes.


A proteolytic enzyme is also sometimes known as protease which as explained earlier is not a specific enzyme, but a type of enzyme. Proteases or proteolytic enzymes are simply enzymes that break down or digest protein. As explained earlier, there are proteolytic enzymes (proteases) that are also pancreatic enzymes, and there are proteolytic enzymes that are derived from plant sources. The most potent pancreatic enzyme by far is called a-Chymotrypsin (also just called Chymotrypsin) which is also an anti-fibrolytic enzyme (an enzyme that is effective against dense fibrous tissue). Coming in second to Chymotrypsin as far as activity for a pancreatic enzyme is Trypsin. Although these are powerful protein digesting enzymes, there are vegetable based enzymes that break down protein as well. One of them in particular is a very potent anti-fibrolytic protease called Natto-Kinase which is derived from the soy plant. The enzyme Bromelain is a proteolytic enzyme derived from pineapples while Papain is a proteolytic enzyme derived from papaya. Both Bromelain and Papain are decent proteolytic enzymes and are in fact much more resilient in the stomach than pancreatic enzymes, but they have a significantly reduced life span when compared to pancreatic enzymes. Pepsin and Bromelain are most commonly found in digestive formulas, but they are also found in some systemic enzyme formulas as well. The most active proteolytic enzymes are more commonly used in systemic enzyme formulas and MUST be enteric coated to be effective. If they aren't enteric coated, they are subject to destruction from stomach acid. Even the vegetable based proteolytic enzymes that survive the introduction of stomach acid must be enteric coated and delivered directly to the duodenum if they are used in a formula that is designed for the absorption of the enzyme into the circulatory system.

It should be noted here that there are those who are allergic to soy. However, there are rarely issues with allergic reactions to the soy based enzyme, Natto-Kinase by those who are allergic to soy. The reason for this is that most allergic reactions to soy are due to the proteins in soy. Natto-Kinase is a very powerful protein digesting enzyme more than capable of breaking down any remaining protein residue that may be found in the extracted Natto-Kinase.


There is another source of a very potent proteolytic enzyme that is neither a pancreatic source nor vegetable source which is called Serratiopeptidase - more commonly known as Serropeptase. It is also know by a number of variations such as Serratiapeptidase, Serrapeptidase, and a number of less common variations. For the sake of this discussion we will refer to it as Serropeptase.

Serropeptase was originally discovered and extracted from the silk worm which was and still is an extremely expensive source. Now, it is by far more commonly extracted from ultra-purified fermenting bacteria. This source appears to be just as active as the silk worm extract, but with one potential concern. There are a small percentage of people who are allergic to the bacteria that Serropeptase is extracted from.  Although the fermented bacteria are heavily filtered, resulting in highly purified Serropeptase, some miniscule residue of the base apparently remains with the enzyme. For the small percentage of people that are allergic to it, they cannot take Serropeptase without having an allergic reaction. The most common side effect is swelling of the face and neck. The allergic reaction usually disappears quickly once they stop taking fermented sourced Serropeptase. Serropeptase is argued by some to be one of the most potent anti-fibrolytic enzymes available and most would agree on that.

However, there seems to be a debate as to whether it is more potent than Natto-Kinase. Whether Natto-Kinase or Serropeptase is more potent, it seems to be clear that they are very close in enzyme activity. For these stated reasons, some prefer to produce supplements only with Natto-Kinase to avoid the issue with the small percentage that are allergic to fermented sourced Serropeptase.

Others manufacture a product that combines Natto-Kinase and Serropeptase making the argument that they both have a purpose and that their functions are not identical. Most formulas that combine Natto-Kinase and pancreatic enzymes do not use Serropeptase for the previously stated reasons.


Systemic enzymes are not a specific enzyme category. Systemic enzyme is a term that is used to describe an enzyme or enzyme formula that is designed to be absorbed into the blood stream and delivered to the entire body, or systemically if you will. Systemic enzymes are usually formulas that contain a mixture of pancreatic enzymes and vegetable source enzymes. What makes them systemic enzymes is the way that the formulas are designed specifically to be delivered to and absorbed systemically in the duodenum as opposed to a digestive aid. There are a few ways that enzymes can be produced and/or utilized to be absorbed systemically, but only one method insures that the integrity of the enzymes survive the destructive properties of stomach acid. In general, stomach acid is a good thing and is essential to proper digestion. However, it can destroy enzymes, particularly pancreatic enzymes, Natto-Kinase, Serropeptase and others. Although fruit based enzymes such as Bromelain and Papain will do just fine in stomach acid, those too must be enteric coated for maximum efficiency if they are designed as a systemic enzyme.

One common technique used to get nutritive enzymes into the duodenum with as little damage as possible to the enzyme is to instruct the person taking them to be certain they are being taken on an empty stomach. Taking them on an empty stomach not only helps the enzyme to survive the stomach, it also helps to get them into the system by not having them tied up digesting food. Even enteric coated systemic enzyme formulas are to be taken on an empty stomach. Usually, an empty stomach is defined as nothing to eat at least one hour before you take an enzyme tablet and/or do not take them for at least two hours after one has eaten. This works great for enteric coated tablets, but only moderately well at best for non-enteric coated enzyme tablets, and is even less effective for non-enteric coated capsules than it is for tablets. When something is taken on an empty stomach, it will indeed stay in the stomach for a far shorter period on an empty stomach compared to a stomach that contains food. In theory, this protects the enzyme tablet (or capsule) from the stomach acid because it is being moved from the stomach to the duodenum much more rapidly. It definitely is being moved more rapidly through the stomach, but how fast is it being moved is the question. There is little doubt that this technique does indeed greatly improve the amount of surviving enzymes through the stomach and into the alkaline rich duodenum where it is absorbed. The concern is that there is still a level of destruction that takes place in the stomach before the tablet arrives in the duodenum. Not a concern for most fruit based enzymes, but it can be a serious concern for pancreatic based enzymes as well as others like Natto-Kinase and Serropeptase. This is even a bigger concern with non-enteric coated capsules for obvious reasons. Tablets are compressed allowing for more protection from stomach acid with an accelerated ascent to the duodenum on an empty stomach. But, a non-enteric coated capsule is very thin and the contents are loosely packed. What is perceived as an advantage of capsules for herbs and other nutrients becomes a serious disadvantage for enzymes. Once the thin outer shell of a capsule is breached by stomach acid, the contents are also subjected to stomach acid and will easily be digested and destroyed. Again, when taken on an empty stomach, some if not most of the contents of the capsule will most likely reach the duodenum and there will be some assimilation into the system. The concern is that the contents of the non-enteric coated capsule could be seriously depleted by the time it gets out of the acid rich environment of the stomach and travels to the alkaline rich environment of the duodenum.


There is only one way to completely protect pancreatic (and other) enzymes through the stomach and insure that they will be absorbed systemically. Only the utilization of an alkaline (ph) sensitive enteric coating will do the job. Unfortunately, many companies use a simple protein based enteric coating that only works moderately well. The concern with using a simple protein coating is twofold. The first concern is that proteins are subject to digestion by stomach acid. Once the acid gets through the protein coating, it can begin to break down and destroy the enzymes it is "protecting". The protein coating will definitely help the tablet get through the stomach better than a tablet/capsule that isn't coated at all, especially if it is taken on an empty stomach. However, this brings up concern number two.

Sometimes the protein based enteric coating helps the tablet/capsule survive the stomach, but unfortunately it sometimes also "protects" it from being broken down in the duodenum where it is supposed to be absorbed.

A ph (alkaline) sensitive enteric coating guarantees survival of the tablet/capsule through the stomach AND guarantees that the coating rapidly comes off in the duodenum. Stomach acid is not capable of digesting an alkaline (ph) sensitive coating. And unlike a simple protein coating, the alkaline (ph) sensitive enteric coating is designed specifically to be broken down only when the tablet/capsule reaches a specific ph level. Once the tablet/capsule with the scientifically engineered coating reaches the specific alkalinity of the duodenum, the coating comes off very rapidly. Most coatings designed for duodenal absorption will come off in an alkaline environment where the ph is 6.7 or higher. In contrast, the ph level of the stomach is typically about 1. This technology was pioneered by the German based Mucos Corporation more than fifty years ago. They were using this technique on their well-known pancreatic enzyme formulas Wobenzyme and Wobe-Mugos long before anyone else even gave the enteric coatings a second thought. For years Mucos Corporation was the world leader in nutritive systemic enzyme sales because their products worked so much better than anyone else's anywhere in the world. The secret was and is in the ph sensitive enteric coating, although it isn't much of a secret anymore. Mucos Corporation still has an outstanding reputation and is still a leader in the industry with its Wobenzyme Med and Wobenzyme-N formulas. However, they no longer have an exclusive on the enteric coating that they pioneered and they no longer have the most potent enzyme formula in the world. Mucos Corporation is mostly coasting on their well-deserved reputation, but is still well respected in the industry. Our Univase Forte is the most potent systemic enzyme formulas in the world with a scientifically engineered alkaline sensitive enteric coating for maximum absorption.


Although their functions are different, digestive enzymes can complement systemic enzymes quite well. Breaking food down properly in the digestive tract can ease much of the resulting inflammation that results when the body attempts to process poorly digested foods. In turn, the anti-inflammatory action of systemic enzymes can further aid in easing remaining inflammation.


More References on Enzymes

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Wolfson D, Olmstead S, Meiss D, Ralston J. Making Sense of Digestive Enzymes: ProThera, Inc.;2008.

Glade MJ, Kendra D, Kaminski MV, Jr. Improvement in protein utilization in nursing-home patients on tube feeding supplemented with an enzyme product derived from Aspergillus niger and bromelain. Nutrition. 2001 Apr;17(4):348-50.

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Wooldridge JL, Heubi JE, Amaro-Galvez R, ET AL. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros. 2009 Dec;8(6):405-17. Epub 2009 Aug 15.

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Park HJ, Jung UJ, Cho SJ, Jung HK, Shim S, Choi MS. Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice. J Nutr Biochem. 2012 Jun 11. [Epub ahead of print]

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Zentler-Munro PL, Assoufi BA, Balasubramanian K, et al. Therapeutic potential and clinical efficacy of acid-resistant fungal lipase in the treatment of pancreatic steatorrhoea due to cystic fibrosis. Pancreas. 1992;7(3):311-9.

Medhekar R. The first quantitative evidence proving the efficacy of supplemental enzymes: National Enzyme Company;2004.

Lin AH, Lee BH, Nichols BL, et al. Starch source influences dietary glucose generation at the mucosal α-glucosidase level. J Biol Chem. 2012 Sep 17. [Epub ahead of print]

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