Univase Forte Proteolytic Enzyme Formula

Univase Forte Proteolytic Enzyme Formula

With Serratiopeptidase

 Supports the Body's Natural Inflammation Response

High Alpha-Chymotrypsin | Trypsin Formulation
No One Makes an Enzyme Formula with as much a-Chymotrypsin

pH-Sensitive Enteric Coated Capsules

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What is Univase Forte Proteolytic Enzyme Formula?

Univase Forte Proteolytic Enzyme Formula is a potent blend of vegetable and animal source proteolytic, amylytic and lipolytic enzymes. This powerful enzyme formula also contains the critical free-radical fighter Catalase, the vital enzyme activator L-Glutathione, concentrated calf thymus, and N-Acetylcysteine, which enhances the body's production of L-Glutathione.

NO ONE makes an enzyme with as much as α-chymotrypsin (an extremely potent and long-lived proteolytic enzyme) as in Univase Forte Proteolytic Enzyme Formula. Compare our ingredients to other so-called "high-potency" enzyme formulations and big-name European-made enzymes, then compare prices. And now we've added Natto-Kinase and Serratiopeptidase to make this formulation simply unbeatable!

It is not difficult to find volumes of information about the benefits of pancreatic and plant source proteolytic enzyme formulas. Nutritional physicians and practitioners have used proteolytic enzymes for years.

RELATED: What Are Enzymes -- Why You Need Them

The Key to Effectiveness of Univase Forte

The key to the effectiveness of any enzyme formulation is getting the enzymes absorbed so that they can be
transported to the target site and activation when they get there. Univase Forte is specially designed by a pharmacist and a biochemist to maximize absorption and ensure the sustained systemic effect of the enzymes.

It used to be that this type of product was best made in tablet form. Since stomach acid is highly destructive to pancreatic enzymes and most plant-source enzymes and capsules quickly break down in the stomach, using old-style pills with enzymes is a bad idea. But advances in technology have changed that. Now vegetarian capsules can be effectively enteric-coated, just like tablets.

For most nutrients, passing through the stomach does no harm and, in some cases, is helpful and even necessary; however, it is not suitable for most enzymes. Since capsules, in the past, could not be enteric-coated, any enzyme formula in a capsule form was likely to be of a greatly diminished value. Beware of the term "enteric-coated."

An enteric coating is placed over a tablet or capsule to protect its contents. However, unless it indicates the wording" pH-sensitive" before enteric coating, you may be getting a simple protein or even vegetable shellac coating. Protein coatings work to a limited degree but can be digested by stomach acid, thus exposing enzymes to premature destruction. Sometimes, the protein coat survives the stomach and, unfortunately, the duodenum, allowing the tablet to pass through the system undigested.

Univase Forte Proteolytic Enzyme Formula is the culmination of more than a quarter century of experience in the proteolytic enzyme field. The formula has evolved into the most potent and effective enzyme supplement available in the world without a prescription.

What is α-Chymotrypsin?

α-Chymotrypsin is a highly potent pancreatic enzyme of which much information is available. Its activity is so great that most enzyme formulas (including the big name European-made ones) on the market only contain 1/2 to 3 milligrams. Univase Forte proteolytic enzyme formula contains 60 milligrams (12,000 units) of α-chymotrypsin per capsule. We have also added the very potent Natto-Kinase 20 mg (400 units) and 1850 mg of Pancreatin. See our technical sheet How to Read an Enzyme Label.

Benefits of Using Enzymes†

Enzymes support healthy blood.

It is common knowledge that fungal forms, parasites, and bacteria consist of protein. Viruses also have a protein coating as a shell that protects them. The enzyme protease breaks down proteins, and since the invaders of our blood system are protein, it makes sense that ingesting protease could break down the protein invaders.

Enzymes support a healthy immune system.

Enzymes transport nutrients to the cells, carry away toxic debris, digest our food, cleanse the blood, distribute hormones by feeding and fortifying the endocrine system, and balance cholesterol and triglycerides levels while not harming the body.

Enzymes help to break down fats.

Research has shown that the enzyme lipase breaks down and digests fat which takes stress off our gallbladder, liver, and pancreas and supports a healthy weight.

Enzymes support healthy cholesterol and triglycerides levels.

Cholesterol and triglycerides are fats that circulate in our bloodstream. The enzyme lipase controls the release of these fats, which could offer protection from certain forms of heart disease, like atherosclerosis.

Enzymes support healthy mental capacity.

Our body uses glucose from the liver to feed and fortify the hypothalamus. When dysfunction with this mechanism, we become fatigued and unable to think clearly. The hypothalamus directs our endocrine system and is responsible for our water balance, body temperature, appetite, and emotions.

Enzymes support a healthy colon.

Foods not adequately digested are stored in the colon, fostering the beginning of digestive concerns. Some researchers estimate that nearly 70% of all illness starts in our colon. Undigested protein putrefies, carbohydrates ferment, and fats turn rancid in our colon. Enzymes properly break down food and help keep the colon free of these toxins. Most natural health doctors and practitioners suggest having two to three bowel movements per day supports a healthy elimination system and a healthy body.

Enzymes support healthy sleep. 

Enzymes enhance the endocrine system. An under-nourished endocrine system may create an imbalance in hormones, negatively affecting our nervous system and sleep patterns. When we are unable to properly digest our food or deliver the nutrients to keep our nervous and endocrine systems in balance, it becomes difficult to experience healthy sleep patterns. During sleep, our body does the most repair and cleansing work.

Enzymes help support a healthy weight.

Many overweight people have a metabolic imbalance or will soon create one. Remember, it is the endocrine system that regulates metabolism. We have a healthy combination once we can fortify the endocrine system, have our bowels working regularly, and properly digest food rather than turning it into fat. Enzymes, especially lipase, will break down our fats properly, which will help us burn fat, thus promoting a healthy weight.

Enzymes support the healthy aging of the skin.

An adequate supply of enzymes is essential for keeping skin young-looking and healthy. Enzymes support the natural aging process by increasing blood supply to the skin, bringing with it life-giving nutrients, and carrying away waste products that can make your skin look dull and wrinkled. Circulation slows down as we get older, and enzymes may help support healthy circulation. Replacing digestive enzymes lost to the aging process may also help restore optimal nutritional status and alleviate numerous health issues.

Enzymes support proper pH balance in our Gl-tract.

Friendly flora such as L. Acidophilus and bifidobacterium are essential to the intestinal tract for maintaining proper pH and controlling the population of potentially pathogenic organisms like clostridium and Candida. Plant flora enzymes prove to be very useful in the pathogen control role of beneficial bacteria. Another valuable role of bacteria is the synthesis of highly favorable natural chemicals in the colon through the fermentation process. These fermented products include molecular species such as natural antibiotics and, very notably, digestive enzymes -- which play a vital role in digesting incompletely digested food substances, especially proteins.

Enzymes support proper pH balance in the urine.

Research shows that a balance of the plant enzymes (lipase, protease, and amylase) consumed by individuals produces a proper urine pH of 6.3 to 6.6 in 24-hour urinalysis.

Why Take Univase Forte?

• Univase Forte does not contain PEG (polyethylene glycol) or citric acid. While an allergy to PEG is rare, it is increasingly recognized and can be severe. Some people have an intolerance to citric acid, which is a digestive tract malfunction. Symptoms include a runny nose or congestion, skin reactions, hives, eczema, and facial swelling.
  
• Univase Forte contains Serratiopeptidase - A proteolytic enzyme, which breaks down nonliving protein tissue into amino acids. It has the added benefit of improving wound healing in general by clearing old or damaged tissue, including blood clots, mucous, cysts, arterial plaque, and fibrosis. Also may help with inflammation and pain.
• Univase Forte proteolytic enzyme formula contains 60 milligrams (12,000 units) of α-chymotrypsin per capsule. Chymotrypsin can help relieve pain and swelling associated with post-operative wounds and inflammatory diseases.
  
• Univase Forte contains Natto-Kinase 20 mg (400 units). Studies show that nattokinase has the ability to dissolve blood clots — which helps maintain good blood vessel structure, improves blood flow, and lowers the risk of heart disease. It can also help lower blood pressure, reducing strain on the heart that can lead to heart attacks.
  
• Univase Forte contains 1850 mg of Pancreatin. Pancreatin helps break down several nutrients, including proteins, fats, and carbohydrates (to be transformed into energy for the body), promotes healthy weight gain and maintenance of healthy weight, promotes the absorption of essential vitamins and minerals.
• Univase Forte is the culmination of more than a quarter-century of experience in the proteolytic enzyme field. The formula has evolved into the most potent and effective enzyme supplement available in the world without prescription.

†Results may vary.

Serving Size: 3 capsules
Servings per container: 200, 400, 800 (depending upon bottle size)

*Capsules have been PH sensitive-coated to insure duodenal assimilation.

Recommendations

As a dietary supplement: take 1-3 capsules three to four times daily between meals or as directed by your healthcare professional.

If Univase Forte is used as a digestive aid, the recommended dosage is 1 or 2 capsules before a meal. For systematic use, the dosages vary, but capsules should be used as far from meals as possible.

CAUTION: If you use the prescription medications acarbose (Precose®) or miglitol (Glyset®), consult your physician before using pancreatin. If you use the medication warfarin (Coumadin®), consult your doctor before using papain (a proteolytic enzyme derived from papaya)

MORE INFORMATION ABOUT ENZYMES

What are Enzymes?

An over simplified explanation of nutritional enzymes is that they are catalysts. That is they cause other reactions to occur in the body or they aid in certain metabolic processes. A nutritional enzyme (an enzyme found in nutritional supplements or in the body) is actually a very specific type of protein. In the case of protein digesting (proteolytic) enzymes, they are literally proteins that break down other proteins. Any unused ingested enzymes are simply converted into amino acids and utilized by the body in a different way. Amino acids are what the human body converts protein based foods into for nutrition. This is why proteolytic or pancreatic enzymes are some of the safest compounds to ingest even in very large quantities.

PANCREATIC ENZYMES

Enzymes that are delivered to the duodenum by the pancreas during the digestive process would be our own naturally produced pancreatic enzymes or a nutritional supplement containing pancreatic enzymes derived from animal pancreas. The most common pancreatic enzymes are: Pancreatin, Trypsin, Alpha Chymotrypsin (also known as a-chymotrypsin), Lipase, and Amylase. There are others, but these are the most common. The enzymes Trypsin and a-Chymotrypsin are potent protein digesting enzymes. The enzyme Amylase digests starch, and the enzyme Lipase digests fat. The enzyme Pancreatin is not really a specific enzyme, but is actually an enzyme slurry that contains all of the previously mentioned pancreatic enzymes.

PROTEASE AND PROPRIETARY BLENDS

There is actually no such enzyme as "protease". Protease merely refers to ANY enzyme that digests protein. The category of protease can include any of the protein digesting pancreatic enzymes as well as any of the protein digesting vegetable, fruit, or other based enzymes. Some enzyme formulas display their contents in a "proprietary blend" of protease that displays an impressive list of enzymes containing trypsin, chymotrypsin and other potent pancreatic enzymes as well a number of vegetable enzymes like Bromelain and  Papain. Quite often the term "proprietary blend" is just a smoke screen to hide the fact that some are using very small amounts of highly active enzymes and large amounts of lesser active enzymes. The concern here is that you just don't know how much of each enzyme is in the Proprietary blend. A "proprietary blend" only tells you what enzymes are in the blend and conceals the actual potencies of the individual enzymes.

PROTEOLYTIC ENZYMES

A proteolytic enzyme is also sometimes known as protease which as explained earlier is not a specific enzyme, but a type of enzyme. Proteases or proteolytic enzymes are simply enzymes that break down or digest protein. As explained earlier, there are proteolytic enzymes (proteases) that are also pancreatic enzymes, and there are proteolytic enzymes that are derived from plant sources. The most potent pancreatic enzyme by far is called a-Chymotrypsin (also just called Chymotrypsin) which is also an anti-fibrolytic enzyme (an enzyme that is effective against dense fibrous tissue). Coming in second to Chymotrypsin as far as activity for a pancreatic enzyme is Trypsin. Although these are powerful protein digesting enzymes, there are vegetable based enzymes that break down protein as well. One of them in particular is a very potent anti-fibrolytic protease called Natto-Kinase which is derived from the soy plant. The enzyme Bromelain is a proteolytic enzyme derived from pineapples while Papain is a proteolytic enzyme derived from papaya. Both Bromelain and Papain are decent proteolytic enzymes and are in fact much more resilient in the stomach than pancreatic enzymes, but they have a significantly reduced life span when compared to pancreatic enzymes. Pepsin and Bromelain are most commonly found in digestive formulas, but they are also found in some systemic enzyme formulas as well. The most active proteolytic enzymes are more commonly used in systemic enzyme formulas and MUST be enteric coated to be effective. If they aren't enteric coated, they are subject to destruction from stomach acid. Even the vegetable based proteolytic enzymes that survive the introduction of stomach acid must be enteric coated and delivered directly to the duodenum if they are used in a formula that is designed for the absorption of the enzyme into the circulatory system.

It should be noted here that there are those who are allergic to soy. However, there are rarely issues with allergic reactions to the soy based enzyme, Natto-Kinase by those who are allergic to soy. The reason for this is that most allergic reactions to soy are due to the proteins in soy. Natto-Kinase is a very powerful protein digesting enzyme more than capable of breaking down any remaining protein residue that may be found in the extracted Natto-Kinase.

SERROPEPTASE

There is another source of a very potent proteolytic enzyme that is neither a pancreatic source nor vegetable source which is called Serratiopeptidase - more commonly known as Serropeptase. It is also know by a number of variations such as Serratiapeptidase, Serrapeptidase, and a number of less common variations. For the sake of this discussion we will refer to it as Serropeptase.

Serropeptase was originally discovered and extracted from the silk worm which was and still is an extremely expensive source. Now, it is by far more commonly extracted from ultra-purified fermenting bacteria. This source appears to be just as active as the silk worm extract, but with one potential concern. There are a small percentage of people who are allergic to the bacteria that Serropeptase is extracted from.  Although the fermented bacteria are heavily filtered, resulting in highly purified Serropeptase, some miniscule residue of the base apparently remains with the enzyme. For the small percentage of people that are allergic to it, they cannot take Serropeptase without having an allergic reaction. The most common side effect is swelling of the face and neck. The allergic reaction usually disappears quickly once they stop taking fermented sourced Serropeptase. Serropeptase is argued by some to be one of the most potent anti-fibrolytic enzymes available and most would agree on that.

However, there seems to be a debate as to whether it is more potent than Natto-Kinase. Whether Natto-Kinase or Serropeptase is more potent, it seems to be clear that they are very close in enzyme activity. For these stated reasons, some prefer to produce supplements only with Natto-Kinase to avoid the issue with the small percentage that are allergic to fermented sourced Serropeptase.

Others manufacture a product that combines Natto-Kinase and Serropeptase making the argument that they both have a purpose and that their functions are not identical. Most formulas that combine Natto-Kinase and pancreatic enzymes do not use Serropeptase for the previously stated reasons.

SYSTEMIC ENZYMES

Systemic enzymes are not a specific enzyme category. Systemic enzyme is a term that is used to describe an enzyme or enzyme formula that is designed to be absorbed into the blood stream and delivered to the entire body, or systemically if you will. Systemic enzymes are usually formulas that contain a mixture of pancreatic enzymes and vegetable source enzymes. What makes them systemic enzymes is the way that the formulas are designed specifically to be delivered to and absorbed systemically in the duodenum as opposed to a digestive aid. There are a few ways that enzymes can be produced and/or utilized to be absorbed systemically, but only one method insures that the integrity of the enzymes survive the destructive properties of stomach acid. In general, stomach acid is a good thing and is essential to proper digestion. However, it can destroy enzymes, particularly pancreatic enzymes, Natto-Kinase, Serropeptase and others. Although fruit based enzymes such as Bromelain and Papain will do just fine in stomach acid, those too must be enteric coated for maximum efficiency if they are designed as a systemic enzyme.

One common technique used to get nutritive enzymes into the duodenum with as little damage as possible to the enzyme is to instruct the person taking them to be certain they are being taken on an empty stomach. Taking them on an empty stomach not only helps the enzyme to survive the stomach, it also helps to get them into the system by not having them tied up digesting food. Even enteric coated systemic enzyme formulas are to be taken on an empty stomach. Usually, an empty stomach is defined as nothing to eat at least one hour before you take an enzyme tablet and/or do not take them for at least two hours after one has eaten. This works great for enteric coated tablets, but only moderately well at best for non-enteric coated enzyme tablets, and is even less effective for non-enteric coated capsules than it is for tablets. When something is taken on an empty stomach, it will indeed stay in the stomach for a far shorter period on an empty stomach compared to a stomach that contains food. In theory, this protects the enzyme tablet (or capsule) from the stomach acid because it is being moved from the stomach to the duodenum much more rapidly. It definitely is being moved more rapidly through the stomach, but how fast is it being moved is the question. There is little doubt that this technique does indeed greatly improve the amount of surviving enzymes through the stomach and into the alkaline rich duodenum where it is absorbed. The concern is that there is still a level of destruction that takes place in the stomach before the tablet arrives in the duodenum. Not a concern for most fruit based enzymes, but it can be a serious concern for pancreatic based enzymes as well as others like Natto-Kinase and Serropeptase. This is even a bigger concern with non-enteric coated capsules for obvious reasons. Tablets are compressed allowing for more protection from stomach acid with an accelerated ascent to the duodenum on an empty stomach. But, a non-enteric coated capsule is very thin and the contents are loosely packed. What is perceived as an advantage of capsules for herbs and other nutrients becomes a serious disadvantage for enzymes. Once the thin outer shell of a capsule is breached by stomach acid, the contents are also subjected to stomach acid and will easily be digested and destroyed. Again, when taken on an empty stomach, some if not most of the contents of the capsule will most likely reach the duodenum and there will be some assimilation into the system. The concern is that the contents of the non-enteric coated capsule could be seriously depleted by the time it gets out of the acid rich environment of the stomach and travels to the alkaline rich environment of the duodenum.

ENTERIC COATINGS

There is only one way to completely protect pancreatic (and other) enzymes through the stomach and insure that they will be absorbed systemically. Only the utilization of an alkaline (ph) sensitive enteric coating will do the job. Unfortunately, many companies use a simple protein based enteric coating that only works moderately well. The concern with using a simple protein coating is twofold. The first concern is that proteins are subject to digestion by stomach acid. Once the acid gets through the protein coating, it can begin to break down and destroy the enzymes it is "protecting". The protein coating will definitely help the tablet get through the stomach better than a tablet/capsule that isn't coated at all, especially if it is taken on an empty stomach. However, this brings up concern number two.

Sometimes the protein based enteric coating helps the tablet/capsule survive the stomach, but unfortunately it sometimes also "protects" it from being broken down in the duodenum where it is supposed to be absorbed.

A ph (alkaline) sensitive enteric coating guarantees survival of the tablet/capsule through the stomach AND guarantees that the coating rapidly comes off in the duodenum. Stomach acid is not capable of digesting an alkaline (ph) sensitive coating. And unlike a simple protein coating, the alkaline (ph) sensitive enteric coating is designed specifically to be broken down only when the tablet/capsule reaches a specific ph level. Once the tablet/capsule with the scientifically engineered coating reaches the specific alkalinity of the duodenum, the coating comes off very rapidly. Most coatings designed for duodenal absorption will come off in an alkaline environment where the ph is 6.7 or higher. In contrast, the ph level of the stomach is typically about 1. This technology was pioneered by the German based Mucos Corporation more than fifty years ago. They were using this technique on their well-known pancreatic enzyme formulas Wobenzyme and Wobe-Mugos long before anyone else even gave the enteric coatings a second thought. For years Mucos Corporation was the world leader in nutritive systemic enzyme sales because their products worked so much better than anyone else's anywhere in the world. The secret was and is in the ph sensitive enteric coating, although it isn't much of a secret anymore. Mucos Corporation still has an outstanding reputation and is still a leader in the industry with its Wobenzyme Med and Wobenzyme-N formulas. However, they no longer have an exclusive on the enteric coating that they pioneered and they no longer have the most potent enzyme formula in the world. Mucos Corporation is mostly coasting on their well-deserved reputation, but is still well respected in the industry. Our Univase Forte is the most potent systemic enzyme formulas in the world with a scientifically engineered alkaline sensitive enteric coating for maximum absorption.

IMPORTANCE OF ENZYMES & ENZYME FUNCTION

Although their functions are different, digestive enzymes can complement systemic enzymes quite well. Breaking food down properly in the digestive tract can ease much of the resulting inflammation that results when the body attempts to process poorly digested foods. In turn, the anti-inflammatory action of systemic enzymes can further aid in easing remaining inflammation.

More References on Enzymes

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Wolfson D, Olmstead S, Meiss D, Ralston J. Making Sense of Digestive Enzymes: ProThera, Inc.;2008.

Glade MJ, Kendra D, Kaminski MV, Jr. Improvement in protein utilization in nursing-home patients on tube feeding supplemented with an enzyme product derived from Aspergillus niger and bromelain. Nutrition. 2001 Apr;17(4):348-50.

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Wooldridge JL, Heubi JE, Amaro-Galvez R, ET AL. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros. 2009 Dec;8(6):405-17. Epub 2009 Aug 15.

Hammer HF. Pancreatic exocrine insufficiency: diagnostic evaluation and replacement therapy with pancreatic enzymes. Dig Dis. 2010;28(2):339-43. Epub 2010 Sep 1.

http://chemistry-today.teknoscienze.com/pdf/MU%20OMEGA3- 08.pdf Accessed October 1, 2012.

Stattin P, Bjor O, Ferrari P, Lukanova A, et al. Prospective study of hyperglycemia and cancer risk. Diabetes Care. 2007 Mar;30(3):561-7.

Vigneri P, Frasca F, Sciacca L, Pandini G, Vigneri R. Diabetes and cancer. Encocr Relat Cancer. 2009 Dec;16(4):1103-23.

Bash, LD, Selvin E, Steffes M, Coresh J, Astor BC. Poor glycemic control in diabetes and the risk of incident kidney disease even in the absence of albuminuria and retinopathy: atherosclerosis risk in communities (ARIC) study. Arch Intern Med. 2008 Dec 8;168(22):2440-7.

Held C, Gerstein HC, Zhao F, et al. Fasting plasma glucose is an independent predictor of hospitalization for congestive heart failure in high-risk patients. American Heart Association 2006 Scientific Sessions. November 13, 2006. Abstract 2562.

Healy L, Howard J, Ryan A, et al. Metabolic syndrome and leptin are associated with adverse pathological features in male colorectal cancer patients. Colorectal Dis. 2011 Jan 20.

Park HJ, Jung UJ, Cho SJ, Jung HK, Shim S, Choi MS. Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipid-regulating enzymes in db/db mice. J Nutr Biochem. 2012 Jun 11. [Epub ahead of print]

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Domínguez-Muñoz JE. Pancreatic exocrine insufficiency: diagnosis and treatment. J Gastroenterol Hepatol. 2011 Mar;26 Suppl 2:12-6.

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Univase Forte Frequently Asked Questions

Q: Why should I take enzymes?

A: Through the processes of stress, aging, poor nutrition, and other factors, including the severity of an injury, the body’s natural anti-inflammatory enzyme system often operates at a substantially reduced level leading to long-term inflammation and resultant pain, edema, and thrombi. Supplemental enzymes can significantly assist in controlling the concerns associated with inflammatory processes.

Q: Why does Univase Forte contain lyophilized calf thymus?

A: Lyophilized calf thymus is included in Univase and Univase Forte because, according to researchers, lyophilized thymus is rich in nuclease enzymes. Nucleases are hydrolases, which cleave the phosphodiester bonds of DNA and RNA. Damaged and foreign RNA/DNA are readily digested by these enzymes. Thus, a viral invader is susceptible to the two-pronged attack of proteases on its’ protein coat and nucleases on its’ genetic material (Wolf and Ransburger, pp.119-133).

Q: Can Univase Forte be taken with any liquid?

A: We highly recommend taking Univase Forte with a full glass of room temperature purified water. When taken with a warm or hot liquid such as coffee or tea, the enteric coating on the Univase Forte capsules could be compromised. Taking the capsules with milk may disturb the absorption of enzymes within the small intestine.