If, for some reason, I had to pick only one supplement to take, turmeric would most likely be my first choice simply because the many important health benefits of turmeric are important to whole body health. Turmeric comes from the root of the Curcuma longa plant and has long been used as a powerful anti-inflammatory in both Chinese and Indian medicine. Traditionally, turmeric was named “Indian saffron” because of its deep yellow-orange color and all through history has been as a condiment, healing remedy and textile dye. Turmeric is best known as one of the ingredients in curry and it also gives mustard its bright yellow color. Native to Indonesia and southern India, turmeric has been harvested for more than 5,000 years. It has served an important role in many traditional cultures throughout the East and is considered an important member of Ayurvedic pharmacopeia.
Health Benefits of Turmeric for Alzheimer’s Disease
Studies suggest that curcumin, which is the biologically active constituent in turmeric, protects against Alzheimer’s disease by turning on a gene that codes for the production of antioxidant proteins. A study published in the Italian Journal of Biochemistry (December 2003) discussed curcumin’s role in the induction of the the heme oxygenase pathway, a protective system that, when triggered in brain tissue, causes the production of the potent antioxidant bilirubin, which protects the brain against oxidative (free radical) injury. Such oxidation is thought to be a major factor in aging and to be responsible for neurodegenerative disorders including dementias like Alzheimer’s disease. Another study conducted jointly by an Italian and U.S. team and presented at the American Physiological Society’s 2004 annual conference in Washington, DC, confirmed that curcumin strongly induces expression of the gene, called hemeoxygenase-1 (HO-1) in astrocytes from the hippocampal region of the brain.
The most active ingredient in turmeric root, bisdemethoxycurcumin, boosts the activity of the immune system in Alzheimer’s patients, helping them to clear the amyloid beta plaques characteristic of the disease. In healthy patients, immune cells called macrophages, which engulf and destroy abnormal cells and suspected pathogens, efficiently clear amyloid beta, but macrophage activity seems to be suppressed in Alzheimer’s patients.
Using blood samples from Alzheimer’s patients, Drs. Milan Fiala and John Cashman have shown that bisdemethoxycurcumin boosts macrophage activity to normal levels, helping to clear amyloid beta. They also found that bisdemethoxycurcumin was more effective in promoting the clearance of amyloid beta in some patients’ blood than others, which hints that a genetic element may be involved. More study showed the genes involved are MGAT III and Toll-like receptors, which are also responsible for a number of other key immune functions. Bisdemethoxycurcumin enhances the transcription of these genes, correcting the immune defects seen in Alzheimer’s patients. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12849-54.
Health Benefits of Turmeric – Anti-Fungal
With more and more research, we are finding out that fungal issues can cause or add to many illnesses and disease. While many herbs, vegetables and fruits have anti-fungal properties, turmeric is proving to provide a much larger punch than most.
In a recent study from the European Journal of Pharmacology, research indicates that the primary polyphenol in turmeric known as curcumin may be the best way to fight cancers which present a fungal element.
“Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections,” addresses the very real concern of invasive fungal infections, as a relevant cause of morbidity and mortality, in those with cancer. The study states, “Effective anti-infection therapy is necessary to inhibit significant deterioration from these infections. However, they are difficult to treat, and increasing antifungal drug resistance often leads to a relapse.” The authors of this study propose curcumin may offer an excellent natural alternative:
“Curcumin, a natural component that is isolated from the rhizome of Curcuma longa plants, has attracted great interest among many scientists studying solid cancers over the last half century. Interestingly, curcumin provides an ideal alternative to current therapies because of its relatively safe profile, even at high doses. To date, curcumin’s potent antifungal activity against different strains of Candida, Cryptococcus, Aspergillus, Trichosporon and Paracoccidioides have been reported, indicating that curcumin anticancer drugs may also possess an antifungal role, helping cancer patients to resist invasive fungal infection related complications. The aim of this review is to discuss curcumin’s dual pharmacological activities regarding its applications as a natural anticancer and antifungal agent. These dual pharmacological activities are expected to lead to clinical trials and to improve infection survival among cancer patients.”
The study also explains that conventional cancer therapies tend to result in damage to the cancer patient’s immune system, which then can contribute to fungal overgrowth. Conventional drugs recommended for fungal infections can cause deliberate harm to the liver and kidneys of cancer patients as well as leading to the development of more aggressive, treatment-resistant fungal infections.
20 Health Benefits of Turmeric
- produces anti-inflammatory effects that rival those of hydrocortisone & ibuprofen
- improves blood circulation
- supports & detoxifies liver
- anti-fungal properties
- natural antiseptic & antibacterial agent
- may prevent metastases of many cancers
- natural painkiller & cox-2 inhibitor
- may help with cystic fibrosis
- aids in fat metabolism
- natural support for arthritis & rheumatoid arthritis
- inhibits growth of new blood vessels in tumors
- speeds up wound healing
- may help prevent Alzheimer’s disease
- reduces risk of childhood Leukemia
- powerful antioxidant
- supports healthy cholesterol
- supports healthy digestion
- supports healthy eyes
- may help with depression
- helps to stabilize blood sugar levels
Ways to Cook Healthy with Turmeric
Your liver’s ability to clear LDL-cholesterol is very important. You can help out your liver by using turmeric to spice up sautéed onions, potatoes and/or cauliflower and also as the main flavor for a creamy vegetable dip. Mix plain organic yogurt with a little omega-3-rich mayonnaise and turmeric, salt and pepper to taste. Serve with raw veggies such as cauliflower, celery, sweet pepper, jicama and broccoli florets. Always choose organic turmeric rather than prepared curry blends. Recent research indicates the amount of turmeric (and therefore curcumin) in curry blends is often minimal. (Tayyem RF et al.,Nutr Cancer)
Another way to incorporate the benefits of turmeric in your healthy diet is to cut cauliflower florets in half and healthy sauté with a generous spoonful of turmeric for 5 minutes. Remove from the heat and toss with cold-pressed olive oil, salt and pepper to taste.
Creamy Turmeric Tea Recipe
(makes 1 cup of tea)
1 cup almond or coconut milk
1/2 teaspoon turmeric
1/2-inch wide round slice of ginger root, peeled & finely chopped
Dash of cayenne pepper
1/2 – 1 teaspoon raw honey
Optional add-ins: cinnamon, cardamom
Gently warm the milk on the stove. In a mug, combine the remaining ingredients. Drizzle a teaspoon of the warmed milk into the mug & mix until the liquid is smooth with no lumps. Add the rest of the milk & mix well. You can leave the pieces of ginger in the tea, or strain it out before drinking.
- Abbey M, Noakes M, Belling GB, Nestel PJ. Partial replacement of saturated fatty acids with almonds or walnuts lowers total plasma cholesterol and low-density-lipoprotein cholesterol. Am J Clin Nutr 1994 May;59(5):995-9. 1994. PMID:16240.
- Aggarwal B. Paper presented at the U.S. Defense Department’s ‘Era of Hope’ Breast Cancer Research Program meeting in Philadelphia, PA, October 5, 2005,. reported in NUTRAingredients.com/Europe “Turmeric slows breast cancer spread in mice.”. 0.
- Ahsan H, Parveen N, Khan NU, Hadi SM. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem Biol Interact 1999 Jul 1;121(2):161-75. 1999. PMID:7690.
- Arbiser JL, Klauber N, Rohan R, et al. Curcumin is an in vivo inhibitor of angiogenesis. Mol Med 1998 Jun;4(6):376-83. 1998. PMID:7540.
- Asai A, Nakagawa K, Miyazawa T. Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice. Biosci Biotechnol Biochem 1999 Dec;63(12):2118-22. 1999. PMID:7550.
- Balasubramanian K. Molecular Orbital Basis for Yellow Curry Spice Curcumin’s Prevention of Alzheimer’s Disease. J. Agric. Food Chem., 54 (10), 3512 -3520, 2006. 10.1021/jf0603533 S0021-8561(06)00353-0, Web Release Date: April 20, 2006. 2006.
- Calabrese V, Butterfield DA, Stella AM. Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer’s disease. Ital J Biochem. 2003 Dec;52(4):177-81. 2003.
- Calabrese V, et. al. Paper on curcumin’s induction of hemeoxygenase-1. Presented at the annual conference of the American Physiological Society, held April 17-21, 2004, Washington, D.C. 2004.
- Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. i>Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. Epub 2006 Jun 6. 2006. PMID:16757216.
- Deshpande UR, Gadre SG, Raste AS, et al. Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride-induced liver damage in rats. Indian J Exp Biol 1998 Jun;36(6):573-7. 1998. PMID:7740.
- Dorai T, Cao YC, Dorai B, et al. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 2001 Jun 1;47(4):293-303. 2001. PMID:16280.
- Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glockner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science. 2004 Apr 23;304(5670):600-2. 2004. PMID:15105504.
- Ensminger AH, Esminger M. K. J. e. al. Food for Health: A Nutrition Encyclopedia. Clovis, California: Pegus Press; 1986. 1986. PMID:15210.
- Fiala M, Lin J, Ringman J, Kermani-Arab V, Tsao G, Patel A, Lossinsky AS, Graves MC, Gustavson A, Sayre J, Sofroni E, Suarez T, Chiappelli F, Bernard G. Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2005 Jun;7(3):221-32; discussion 255-62. 2005. PMID:16006665.
- Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer’s disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12849-54. 2007. PMID:17652175.
- Fortin, Francois, Editorial Director. The Visual Foods Encyclopedia. Macmillan, New York. 1996.
- Grieve M. A Modern Herbal. Dover Publications, New York. 1971.
- Gururaj A, Kelakavadi M, Venkatesh D et al. Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem Biophys Res Commun 2002 Oct 4;297(4):934. 2002.
- Hidaka H, Ishiko T, Furunashi T et al. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impacgt on human pancrreatic carcinoma cell growth by autocrine regulation. Cancer 2002 Sep 15;96(6):1206-14. 2002.
- Kang BY, Chung SW, Chung W et al. Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophage by curcumin. Eur J Pharmacol 1999 Nov;384(2-3):191-5. 1999.
- Kang BY, Song YJ, Kim KM et al. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages. Br J Pharmacol 1999 Sep;128(2):380-4. 1999.
- Khor TO, Keum YS, Lin W, Kim JH, Hu1 R, Shen G, Xu1 C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice. Cancer Research. 2006 Jan; 66(2): 613-621. 2006. PMID:16423986.
- Lim GP, Chu T, Yang F, et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001 Nov 1;21(21):8370-7. 2001. PMID:16240.
- Nagabhushan M, Amonkar AJ, Bhide SV. In vitro antimutagenicity of curcumin against environmental mutagens. Food Chem Toxicol. 1987 Jul;25(7):545-7. 1987. PMID:3623345.
- Nagabhushan M, Bhide SV. Curcumin as an inhibitor of cancer. J Am Coll Nutr. 1992 Apr;11(2):192-8. 1992. PMID:1578097.
- Nagabhushan M, Nair UJ, Amonkar AJ, D’Souza AV, Bhide SV. Curcumins as inhibitors of nitrosation in vitro. Mutat Res. 1988 Nov;202(1):163-9. 1988. PMID:3054526.
- Nagabhushan M. Research presented at the Children with Leukaemia Conference, www.leukaemia.org, September 2004. 2004.
- Nakamura K, Yasunaga Y, Segawa T et al. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol 2002 Oct;21(4):825-30. 2002.
- Natarajan C, Bright JJ. Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-2 prodeuction, IL-12 signaling and Th1 differentiation. Genes Immun 2002 Apr;3(2):59-70. 2002.
- Olszewska M, Glowacki R, Wolbis M, Bald E. Quantitative determination of flavonoids in the flowers and leaves of Prunus spinosa L. Acta Pol Pharm 2001 May-2001 Jun 30;58(3):199-203. 2001. PMID:16270.
- Parfk SY, Kim DS. Discovery of natural products from Curcuma longa that protects cells from beta-amyloid insult: a drug discovery effort against Alzherimer’s disease. J Nat Prod 2002 Sep;65(9):1227-31. 2002.
- Peschel D, Koerting R, Nass N. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr Biochem. 2007 Feb;18(2):113-9. Epub 2006 May 18. 2007. PMID:16713233.
- Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobson K. Curcumin attenuates DNB-induced murine colitis. Am J Physiol Gastrointest Liver Physiol. Jul;285(1):G235-43. Epub 2003 Mar 13. 2003. PMID:12637253.
- Shah BH, Nawaz Z, Pertani SA, et al. Inhibitory effect of curcumin, a food spice from turmeric, on platelet- activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signa. Biochem Pharmacol 1999 Oct 1;58(7):1167-72. 1999. PMID:7670.
- Shishodia S, Amin HM, Lai R, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005 Sep 1;70(5):700-13. 2005. PMID:16023083.
- Soni KB, Kuttan R. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5. 1992. PMID:1291482.
- Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Curcumin content of turmeric and curry powders. Nutr Cancer. 2006;55(2):126-31. 2006. PMID:17044766.
- Wills RB, Scriven FM, Greenfield H. Nutrient composition of stone fruit (Prunus spp.) cultivars: apricot, cherry, nectarine, peach and plum. J Sci Food Agric 1983 Dec;34(12):1383-9. 1983. PMID:16280.
- Wood, Rebecca. The Whole Foods Encyclopedia. New York, NY: Prentice-Hall Press; 1988. 1988. PMID:15220.
- Wuthi-udomler M, Grisanapan W, Luanratana O, Caichompoo W. Antifungal activity of Curcuma longa grown in Thailand. Southeast Asian J Trop Med Public Health 2000;31 Suppl 1:178-82. 2000. PMID:16270.
- Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of Abeta oligomers and fibrils and binds plaques and reduces amyloid in vivo. J Biol Chem. 2004 Dec 7; [Epub ahead of print]. 2004. PMID:15590663.
- Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer’s disease patients. J Alzheimers Dis. 2006 Sep;10(1):1-7. 2006. PMID:16988474.
- Chen J, He ZM, Wang FL, Zhang ZS, Liu XZ, Zhai DD, Chen WD. Curcumin and its promise as an anticancer drug: An analysis of its anticancer and antifungal effects in cancer and associated complications from invasive fungal infections. Eur J Pharmacol. 2016 Feb 5;772:33-42. doi: 10.1016/j.ejphar.2015.12.038. Epub 2015 Dec 23.
- Ji, Sayer. Yeast Is A Cause of Cancer and Turmeric Can Kill Both, Research Confirms. GreenMed Info LLC. January, 2016.