Trevinol Professional Enzymes (300-count) Vegetarian Formula


Trevinol Professional Vegetarian Formula (300 ct) consists of a clinically developed Proprietary Blend (531,000 Units of Enzymatic Activity) of systemic enzymes, including Serrapeptase, Nattokinase, Bromelain, Serraspore Blend™ (Encapsulated Lactobacillus Sporogenes). Trevinol Professional Enzymes are scientifically formulated for fibrin defense to protect from the damage caused by excess fibrin buildup and the resulting inflammation. † †Results may vary.

Fibrin Defense | Vegetarian Formula

Systemic Enzyme Formula with Serrapeptase – Nattokinase – Bromelain & More!
531,000 Units of Enzymatic Activity Per Serving

NOTE: Because of our commitment to providing our customers with the freshest of products, Trevinol Professional
is shipped directly from the manufacturer to the customer USPS Priority Mail.

No Titanium Dioxide | No Animal Derivatives | No Artificial Colors or Flavors
Produced in the USA and GMP Compliant | May Only Be Purchased Through A Healthcare Professional

Trevinol Professional Enzymes consists of a clinically developed proprietary blend of systemic enzymes that includes Serrapeptase, Nattokinase, Bromelain, proteolytic enzymes, and proven antioxidants. Trevinol Professional was scientifically formulated for fibrin defense to protect from damage caused by excess fibrin buildup and the resulting inflammation.

As we mature and the overall production of metabolic enzymes in the body decreases, the result can be serious health concerns.

Joint Stiffness and Inflammation

Trevinol Professional Enzymes supports reduction in excess fibrin levels, cardiovascular well-being, reduced inflammation, enhanced joint health, and immune system strength. This carefully produced formula helps balance the body's natural chemistry to improve general wellness and help guard against toxins and impurities in the blood.*

The ingredients in Trevinol Professional Enzymes have been studied for over two decades and are recommended by healthcare professionals worldwide.

The Trevinol Proprietary Enzymes Blend is the most advanced systemic enzyme therapy currently available. Scientifically developed, this exclusive formulation may be more potent than other leading systemic enzyme blends and is 100% vegetarian.

Trevinol was formulated to replenish the enzymes and important antioxidants that are depleted from the body as we age. This unique formula provides a complete range of "proteolytic" (protein digesting) enzymes coupled with our Enzyme Catalyst Blend of anti-oxidants to prevent the formation of fibrin.

Trevinol's proprietary formulation is active within the bloodstream to remove unwanted wastes and convert undigested food matter into valuable energy*

Reduction of Fibrin

Fibrin is an elastic, insoluble, mesh-like-looking protein produced by the action of blood clotting and impacts a wide variety of health conditions. Fibrin plays a key role in the healing process in which molecules of fibrin form network trapping cells and debris that seal off a damaged vessel. Unwanted fibrin formation, however, can occur inside healthy blood vessels and tissue, causing thromboses. Researchers now believe that excess fibrin accumulation is a major cause of inflammation, arthritic swelling, scar tissue build-up, and related cardiovascular disorders.

The Hydrolase CoFactors Blend developed by Landis Revin for Trevinol works in reducing inflammation, enhancing circulation, and improving joint health and mobility. The result is reduced pain and arthritic symptoms.

Trevinol Professional Enzymes provides a synergistic blend of fibrin-reducing enzymes is designed to remove fibrin buildup and promote greater well-being.

Proteolytic enzymes such as Serrapeptase and Nattokinase, those found in Trevinol, are recognized to potentially and substantially lower C-Reactive protein levels (CRP), an inflammation marker linked to cardiovascular disease. C-Reactive Protein is produced by the liver and has been linked to acute arterial inflammation. Triggered by the immune system, inflammation helps the body attack disease-causing germs, repair injured tissue, and promote healing. When the fight is over, however, the actions of the immune system often leave residual damage.

Recent studies indicate that inflammation is the driving force behind atherosclerosis, in which plaque accumulates within the walls of the arteries, reducing blood flow and increasing the risk of stroke. According to a Harvard School of Public Health study, high levels of C-Reactive Protein in the blood were associated with a 79% higher risk of heart disease in men and women over a period of 8 years.

Many professionals now feel that high CRP levels may even be a better predictor of heart attacks than cholesterol levels. According to researchers directing the Framingham Heart Study, a study of over 7,900 men and women supported by the National Heart, Lung, and Blood Institute, and published in The Journal of Circulation, (February 2006) the results confirmed that aggressively treating cardiovascular disease risk factors can significantly reduce the risk of cardiovascular disease and add 10 years to your life. The results were based on findings from the study of 3,564 men and 4,362 women.

Trevinol Professional Enzymes were developed to promote enhanced circulation, improved blood flow, and lower blood pressure. This may be accomplished by the reduction of excess fibrin and unwanted debris within the cardiovascular system, while preventing gastrointestinal stress, or damaging the liver. For people currently experiencing some form of heart disease, Proteolytic enzymes have shown promising science in the ability to dissolve arterial plaque, diminish scar tissue, and reduce LDL cholesterol. Nattokinase has been clinically shown to remove arterial blockages over 50% faster than the body's own natural Proteolytic enzymes. The combination of Serrapeptase, Nattokinase, and the Enzyme Catalyst Blend found in Trevinol offers a complete fibrinolytic complement of enzymes.

Free Radical Defense

Trevinol Professional by Landis Revin is the only systemic enzyme formula containing our unique blend of key antioxidants designed to reduce free radicals. These select nutrients play a critical role in preventing fibrin buildup by giving your body a defense at the cellular level to deactivate free radicals before they attack and damage your cells.*

Compare our proprietary formula to other products.

Systemic Enzymes Explained

Why are Enzymes Important?

Many of us are familiar with the digestive enzymes found in the stomach and intestines; they process the various foods we eat. However, other types of enzymes are reaction-causing agents which make breathing, growth, healing and other body functions possible.

Enzymes more than just sustain life, they are catalysts for virtually every biological and chemical reaction in the body. Without enzymes, life itself could not exist. As we age, however, our own enzyme production significantly diminishes. The enzymes we need to maintain healthy joints, a strong immune system, good circulation, and overall balanced well-being are less available.

As we begin to mature and these enzyme levels decline, we become subject to enzyme deficiency. This can lead to a wide variety of health issues, including unhealthy amounts of fibrin accumulating in our joints, our blood and veins, and throughout our system.

Trevinol Professional™ Enzymes contain 100% vegetable-derived enzymes which are readily bioavailable and therefore, chemically more effective than our body's own natural enzymes.

These enzymes attack fibrin and may reduce the impact of fibrin buildup associated with arthritic and inflammatory conditions, plaque build-up within the arteries, scar tissue, production of C-Reactive Protein (CRP), and Fibrosis.

What are "Systemic Enzymes"?

Systemic enzymes operate throughout every system and organ in our body. Unlike digestive enzymes found in the gastrointestinal tract, systemic enzymes create or accelerate biochemical reactions. Basically, they are “agents of change”.

Unlike the digestive enzymes found in the stomach and intestines which are responsible for processing food. Systemic Enzymes are reaction-causing agents allowing cells to regenerate, enable breathing, healing and make other body functions possible. Trevinol Professional™ contains plant-derived enzymes, which pass easily through the stomach and digestive tract and are rapidly absorbed into the bloodstream. These enzymes work "systemically" or throughout the entire body. Trevinol employs a clinically proven delivery system that ensures that these enzymes are distributed within your body and organs while in their most active state.

Proteolytic Enzymes

Proteolytic enzymes (meaning "protein-dissolving") often in the form of Serrapeptase are ubiquitous in nature. They are found in animals, plants, bacteria, and fungi. Human beings produce enzymes to help digest our food, but we also produce numerous other types, which act to control virtually every regulatory mechanism in our bodies. These complex enzymes break down and digest proteins into fragments. Recent scientific evidence supports the use of proteolytic enzyme supplements for enhancing digestive function and for speeding recovery from injury/surgery and reducing swelling and inflammation.

Protease is one form of proteolytic enzyme which demonstrates such an ability. Its role is critical as incomplete protein digestion creates problems for the body including the development of allergies and the formation of toxins. Undigested proteins have been linked to many health concerns, including foreign invaders in the intestinal tract. Some of these foreign invaders are parasites. Protease is largely responsible for keeping the small intestines free from parasites. A lack of protease increases the risk of intestinal infection including an overgrowth of the yeast Candida. Protease also delivers the specific nutrients necessary to promote healthy muscle tissue and vibrant immune system function.

Commonly recognized benefits of Proteolytic Enzymes:

Reduce inflammation:

Inflammation is a natural response of the body to injury. However, excessive inflammation can result in painful swelling and slow the healing process. Proteolytic enzymes reduce inflammation by neutralizing the bio-chemicals of inflammation (bradykinins and pro-inflammatory eicosanoids) to levels where the synthesis, repair, and regeneration of injured tissues can take place. Reducing inflammation can have an immediate impact on improved heart health, arthritis, surgical recuperation, and sports injury prevention and recovery. Enzymes can be very useful for managing sprains, strains, fractures, bruises, and contusions.

Blood Cleansing:

Proteolytic enzymes are the primary tools the body uses to "digest" organic debris in the circulatory and lymph systems. This process of cleansing the blood of debris can significantly improve blood pressure, circulation and reduce cardio risk factors.

Dissolving Fibrin:

Excess fibrin in the blood can result in blockages and the risk of clots. Certain specialized proteases such as nattokinase are extremely effective at improving the "quality" of blood cells, optimizing the ability of blood to flow through the circulatory system, and reducing the risk of clots. This is extremely important in reducing the risk of stroke. Many patients now use proteolytic enzymes during long plane flights to minimize the potential of blood clots in the legs.

Strengthen immune system:

The primary vehicle the immune system uses for destroying invaders is enzymes. Supplementation with the proper types of enzymes may significantly improve the ability of your immune system to perform its tasks. Macrophages, for example, literally digest invaders with proteolytic enzymes.

Reduction of Bacteria Viruses and Fungi:

Bacteria, viruses, molds, and fungi are protein/amino acid-based. Proteolytic enzymes, always most effective when taken between meals, can enter the bloodstream and digest these invaders.

Elimination of autoimmune diseases:

Large undigested proteins can make their way into the bloodstream and form Circulating Immune Complexes (known as CIC’s) which trigger allergies and autoimmune diseases. Supplementation with proteolytic enzymes may remove these potentially dangerous CICs from the body, thereby reducing allergies and autoimmune conditions. This may also kelp with sinusitis and asthma conditions.

Dissolving of scar tissue:

Scar tissue is made of protein. Proteolytic enzymes have the unique ability to effectively "digest" dead cellular matter and scar tissue while leaving active, living cells intact. This is particularly true in the circulatory system.

†Results may vary.


Fibrin Defense Blend: 1,200 mg (Providing 531,000 FU)

Phytofiber Complex:
Lactospore® Lactobacillus sporogenes (195 million CFU) and Inulin (as chicory inulin)

Hydrolase Enzyme CoFactors:
Bromelain, Serrazimes®, Protease, Papain, and Nattokinase

Enzyme Catalyst Blend:
Quercetin, Alpha-Lipoic Acid, USP Coenzyme Q-10

Magnesium (as magnesium oxide) 45 mg

Other Ingredients:
Hypromellose, magnesium stearate, microcrystalline cellulose, and silica.

May contain soy.


Serving Size: 3 Vegetable Capsules

Servings Per Container: 100

531,000 Fibrinolytic Units (FU's) per 1,500 mg**

Suggested Usage

Dietary Supplement: Three(3) Capsules, daily with 8oz of water.

Loading Phase: During the initial Three (3) weeks of usage, take Six (6) Capsules daily. You may continue at this dosage level if you are treating severe inflammation or a chronic disorder.

Maintenance Dose: Three(3) Capsules Daily

Important Note: Take at least 90 Minutes before or after a meal, "away from food", or as your physician recommends."

The medical use of enzymes as anti-inflammatory agents goes back many years. In the early 1950s, it was discovered that certain enzymes could relieve the symptoms of many different inflammatory conditions, including rheumatoid arthritis, ulcerative colitis, and atypical viral pneumonia. Subsequently, the use of special enzymes was found to be beneficial in counteracting post-surgical swelling (edema), treating thrombophlebitis and lower back strain, and rapidly healing bruises caused by sports injuries.

Today, there is mounting evidence of the value of Proteolytic enzymes in reducing inflammation which can lead to circulatory problems, coronary heart disease, and stroke. Recently, American Heart Association and the Centers for Disease Control and Prevention published a joint scientific statement supporting the use of inflammatory markers in clinical and public health practice. Most studies show that the higher the C-Reactive Protein levels (known as "CRP”), the higher the risk of developing a heart attack. Recent scientific studies have found that the risk for heart attack in people in the upper third of CRP levels is twice that of those whose CRP is in the lower third.

Maintaining a strong and efficient cardiovascular system is central to living a long and productive life. According to the Heart Lung Vascular Institute at the University of Tennessee, Heart Disease is the leading cause of death in men and women in the United States, and it's not just a result of aging. Certain lifestyle habits and genetic factors allow the heart and the body's network of blood vessels to become overworked and damaged, often due to inflammation.

Healthy Lifestyle Strategies

As we age, our bodies produce fewer enzymes which may lead to serious health conditions, including the buildup of fibrin in our joints, veins, and throughout our system. Trevinol ES was developed to reduce fibrin levels, promote enhanced circulation, restore joint health and mobility, boost immune strength and reduce inflammation and scar tissue.

Recent studies have shown the correlation between elevated vascular inflammation, LDL (bad) cholesterol, and increased risk of heart disease. Trevinol Professional contains key nutrients formulated to reduces levels of vascular inflammation, arterial plaque, and bad cholesterol.

We believe that with regular professional healthcare, a healthy diet, low in cholesterol and saturated fats, proper exercise, and an enzyme supplement, such as Trevinol Professional, you can help maintain your normal enzyme levels and live a healthier lifestyle.

Hydrolase Enzyme CoFactor Blend

The Hydrolase™ Enzyme CoFactors Blend developed by Landis Revin for Trevinol Professional works to aid in circulation, joint health, mobility, healthy aging, the reduction of inflammation, sports injury recuperation, and much more.

The word “arthritis” is derived from arthron, the Greek term for joint, and the suffix itis, meaning disease or inflammation. In fact, arthritis, comprising more than 100 diseases and conditions affecting joints and connective tissues, is a cause of pain, inflammation, and loss of mobility. More than 46 million Americans have arthritis-related conditions, and another 23 million suffer from chronic joint problems.


Serrapeptase, also known as Serratiapeptidase, is a vegetarian enzyme that naturally eases pain, swelling, and inflammation from overexertion, injury, and everyday activities. Classified as a proteolytic enzyme, it is isolated from the non-pathogenic enterobacteria Serratia E15.

Serrapeptase works to break down extraneous fibrin, mucus, and other compounds that congregate when the body’s natural repair functions are working. It promotes cardiovascular and arterial health, joint and muscle repair and supports the body's natural process for drainage and healing.

In simple terms, Serrapeptase digests dead tissue, blood clots, cysts, and arterial plaque. This Proteolytic or "Protein digesting" enzyme is one of the many potent proteolytic enzymes available today that exhibits an unusually high fibrinolytic activity and is generally well tolerated.

Serrapeptase is a powerful inflammation normalizer that acts as a potent force to reduce systemic fibrin concentrations within the body. When it's combined with the other key ingredients in Trevinol, the results can be significant. This enzyme, like the other enzymes used in Trevinol, breaks down "non-living" matter in the human body. This action may promote a reduction in levels of dead tissue, and may also promote normal mucous levels both in the sinus and lung. Serrapeptase is a super protein-digesting enzyme, which has many implications as to its high level of performance.


Nattokinase is a systemic (works through the whole body) enzyme that is created when boiled soybeans are fermented with the probiotic bacteria Bacillus subtilis natto to create the traditional Japanese soy food called natto. Nattokinase supports the fibrinolytic clearing system in the body which is responsible for healthy circulation, by helping to break down fibrin protein deposits in the bloodstream to promote and enhance healthy blood flow.

What Causes Most Heart Attacks and Strokes?

Many of us develop plaque: a buildup of cholesterol and other materials in the walls of our arteries. Over time this plaque can restrict the flow of oxygen-rich blood throughout the body. In addition, high blood pressure can place stress on the plaque as blood flows past it.

Plaque may eventually rupture, causing platelets to stick together and form a clot—which can limit or completely stop the flow of blood to part of the heart or brain. This often results in a heart attack, heart-related chest pain, or stroke. So although high cholesterol and high blood pressure play a role in the process, clot formation can often be the direct cause of a heart attack or stroke. That's why it's important to reduce the risk of clot formation.

The benefits of Nattokinase (Fibrinolytic enzyme) include:

  • Supports normal blood viscosity and pressure
  • Supports Lower LDL cholesterol
  • Helps maintain normal cardiovascular health
  • Strong Antioxidant effects may be beneficial to healthy aging
  • Potent Fibrinolytic activity reduces systemic fibrin concentrations
  • Helps eliminate damaging free radicals

Research In The United States

Dr. Martin Milner of the Center for Natural Medicine in Portland, Oregon, and Dr. Kouhei Makise of the Imadeqawa Makise Clinica in Kyoto, Japan was able to launch a joint research project on nattokinase and write an extensive paper on their findings. "In all my years of research as a professor of cardiovascular and pulmonary medicine, natto and nattokinase represents the most exciting new development in the prevention and treatment of cardiovascular-related diseases,"

Dr. Milner said. "We have finally found a potent natural agent that can thin and dissolve clots effectively, with relative safety and without side effects."

About C-Reactive Protein (CPR)

The amount of CRP produced by the body varies from person to person and is affected by lifestyle as well as genetic makeup. Higher CRP levels can significantly increase inflammation throughout the body. People who smoke and those living sedentary lifestyles, or who are overweight or have high blood pressure are most at risk.

Research shows that too much inflammation can have adverse effects on the blood vessels which transport oxygen and nutrients throughout our bodies. Atherosclerosis, which involves the formation of fatty deposits or plaques in the inner walls of the arteries, is now considered in many ways an inflammatory disorder of the blood vessels, similar to how arthritis is an inflammatory disorder of the bones and joints. Inflammation not only affects the atherosclerotic phase of heart disease, but also the rupturing of plaques which can then travel and interfere with blood flow, causing a heart attack.

Reducing levels of C-Reactive Protein can have a beneficial effect on cardiovascular health and joint and bone wellness.


A powerful protein-digesting or "proteolytic" enzyme that displays a number of biochemical activities in addition to protein digestion, including inhibition of platelet aggregation, reduction of pro-inflammatory prostaglandin formation, fibrinolytic activity, enhanced wound healing, cardiovascular and circulatory enhancement. Extracted from the stem of the pineapple, and unlike most enzymes, Bromelain is active both in the acid environment of the stomach and the alkaline environment of the small intestine. Bromelain may guard against the formation of fibrin, and once in the blood, it may promote normal inflammation levels and maintain healthy blood flow*


A proteolytic enzyme derived from the papaya. It is capable of cleaving and splicing proteins and peptides into free-form amino acids, which are necessary for many biochemical reactions in the body. Papain may also be useful in the elimination of parasites in the gastrointestinal tract by simply digesting them. Papain has acquired the reputation of selectively being able to digest dead tissue without affecting the surrounding live tissue. Papain comes to the rescue when the body requires a cleansing of the dead cellular material.*


Protease (also known as "proteinases" or "peptidases") are enzymes that are essential for all life. They play pivotal regulatory roles in the conception, digestion, growth, maturation, and aging of all organisms. Proteases regulate most physiological processes by controlling the activation, synthesis and turnover of proteins.

This unique enzyme acts as a sharp knife, cutting long sequences of amino acids (called peptides) into fragments that fold into proteins. Amino acids are common building blocks for all life. Organisms (including humans and other mammals) extract them from their environment (diet) or synthesize them, and link them together to form biological polymers (called polypeptides). Proteases are essential for the synthesis of all proteins, controlling protein composition, size, shape, turnover, and eventual depletion.

Serraspore Lactobacillus Blend

Designed to enhance the effectiveness of our systemic enzyme blend, Serraspore™ Lactobacillus is a preparation containing viable spores of L. sporogenes.

The benefits of Serraspore™ Lactobacillus Proprietary Blend include:

  • Prevent the spread of harmful bacteria within our bodies
  • Boosts our own immune systems
  • Supports Respiratory health
  • Increases Resistance to Virus & Germs
  • Reduces Fatigue

An optimally functioning intestinal system is crucial to the health of the whole body. The human gastrointestinal tract harbors trillions of microorganisms, some beneficial to our health and some not. The cells that line the intestines, called villi, form a single layer that regulates digestion and absorbs the digested products. Friendly (probiotic) bacteria live attached to the villi, finding food and shelter, and in turn providing benefits.*

Lactobacillus take up residence primarily in the wall of the small intestine, where they provide many functions, including the normalization of pH, promotion of digestive function, and stimulation of immune response and antimicrobial activity. They can help prevent vaginal yeast infections, and support healthy cholesterol levels.

L. sporogenes is a particularly hardy member of the lactobacillus group. It is stably encapsulated in spores that can resist stomach acid, antibiotics, and other chemicals, heat, radiation, and freezing.

Lactobacilli have been shown to be effective in the treatment of a variety of disorders, including gastrointestinal disorders, certain infections, hepatic encephalopathy, hypercholesterolemia, and conditions related to deficiency of vitamins B. Lactobacilli have proved to be useful in delaying the induction of tumors and have found use in the prevention of colon cancer. Lactobacilli are thus valuable therapeutically and are often used as adjuvants to antibiotic therapy.

Serraspore™ Lactobacillus stimulates our own immune system to protect against infection, prevent the growth of harmful bacteria and increase our resistance to infectious agents. These "friendly bacteria" activate and enhance our own immune systems for greater well-being.*

Scientists N.W. Nowotelnow and L.M. Horowitz-Wlassowa first isolated L. sporogenes in 1933 and gave it its name. This was changed to Bacillus coagulans in the 5th edition of Bergey's Manual of Determinative Bacteriology but was eventually given its original name back to honor its discoverers.

Lactobacilli improve the digestibility of ingested food constituents and the bioavailability of nutrients, including the enzymes found in Trevinol Professional.

Enzyme Catalyst Blend

Antioxidants provide your body a defense at the cellular level by stabilizing or deactivating free radicals before they attack and damage our cells.

Alpha Lipoic Acid (ALA)

This vitamin-like antioxidant sometimes referred to as the "universal antioxidant," is readily absorbed by the body as a supplement. ALA exists as both fat and water-soluble, which enables it to function in many different tissues providing you with protection against the oxidative damage of free radicals. ALA may also promote healthy blood flow to nerves, which may promote normal transmission of nerve impulses. It is also capable of binding and helping to eliminate heavy metals, repairing damaged molecules, and may also promote healthy liver function. ALA also has the unique ability to directly recycle, re-activate, and extend the lifespan of other antioxidants such as vitamin C, and Vitamin E, creating an antioxidant framework that is highly effective.

Coenzyme Q10 - Ubiquinone

This unique vitamin-like substance is fat-soluble and is present in every cell of the body. It serves as a coenzyme for several of the key enzymatic steps in the production of energy within the cell. Clinical research suggests that CoQ-10 decreases the proliferation of free radicals, which supports a healthy immune system. It also stimulates your metabolism to aid the body in the conversion of food to energy and is essential to the production of ATP, cell respiration, electron transfer, and the reduction of cellular oxidation.

Recently published in the February 2006 edition of the Journal of the American Academy of Dermatology, and earlier in the January edition of the prestigious journal Neurology, new research studies have confirmed the benefits of CoQ10.

As research continues, there is growing clinical evidence that Coenzyme Q-10 (CoQ10) seems to have an amazing capability for promoting healthy immune function, cellular and muscle health. It's also effective for slowing the progression of a devastating loss of brain cells (neurologic disease) that control movement as we age. And, a study that was published in the Archives of Neurology a couple of years ago indicating that CoQ10 was actually able to slow the progression of Parkinson's disease.

In addition, CoQ-10 helps maintain normal cardiovascular function and is essential for enzymes to function in the body.


Quercetin belongs to a class of water-soluble plant pigments called flavonoids. The term flavonoid refers to a class of plant secondary metabolites based around a phenylbenzopyrone structure. Flavonoids are most commonly known for their antioxidant activity. Flavonoids are also commonly referred to as bioflavonoids in the media

Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. For example, it inhibits both the manufacture and release of histamine and other allergic and inflammatory mediators. As an antioxidant, it protects LDL cholesterol ("bad" cholesterol) from becoming damaged. A variety of evidence indicates that quercetin possesses potent antioxidant properties. Cardiologists believe that damage to LDL cholesterol is an underlying cause of heart disease. Quercetin blocks an enzyme that leads to the accumulation of sorbitol, which has been linked to nerve, eye, and kidney damage in those with diabetes.

Quercetin functions like other bioflavonoids in enhancing the collagen network (structural integrity) of blood vessels and is known for its antiviral activity. It also is considered a phytoestrogen (i.e., a plant substance with similar functions as that of estrogen). Some phytoestrogens are believed also to have antiestrogenic effects that might lead to reduced risks of certain illnesses.

Enteric Coating

Enzymes are basic proteins that act as catalysts to regulate the speed at which biochemical reactions occur in our body. They affect the rate but do not alter the direction or nature of the reactions.

You may be familiar with a term known as "Enteric Coating". This is a barrier applied to the outside of a tablet containing certain enzymes. The purpose is to control the location in the digestive system where these enzymes are absorbed.

Enzymes derived from animals, such as Pancreatin and Chymotrypsin may need to be enterically coated because their effectiveness will be reduced by stomach acids or other enzymes if left unprotected. They begin breaking down in the intestines. Such is the case with animal-derived enzymes.


The pharmaceutical-grade enzymes developed for Trevinol Professional are encapsulated in a vegetarian gel capsule and avoid the heating process used in most compressed tablets. This process can degrade or damage the effectiveness of certain enzymes. Trevinol does not contain any fillers or bonding agents commonly found in compressed tablets.

Our research demonstrates that capsules containing enzymes in a powdered form are more bio-available (easily assimilated) than compressed tablets. This is important because a tablet that breaks down too slowly will fail to provide the specific nutrient benefit at the right intestinal sites, thereby decreasing absorption and potentially causing gastrointestinal upset.

There are many advantages of using supplemental microbial enzymes as opposed to animal-derived enzymes. Fermented enzymes have been used in foods for centuries. Microbial enzymes have been specially selected on the basis of each enzyme's unique characteristics. Fermented enzymes exhibit broad ranges of pH, temperature, and substrate specificities. Supplemental microbial enzymes are chosen on their ability to work within the gastrointestinal system.

Specially selected for compatibility with the body's temperature, microbial enzymes also exhibit activity across a broad pH range. Unlike supplemental enzymes of animal origin, microbial enzymes work at the pH found in the upper stomach. Food sits in the upper portion of the stomach for as long as an hour before gastric secretions begin action. Several studies conducted at major universities have shown that the enzymes in saliva continue their digestive activity in the upper stomach and can digest up to 30% of the ingested protein, 60% of ingested starch, and 10% of ingested fat during the first 30 to 60 minutes after consumption. Although salivary enzymes accomplish a significant amount of digestion, their activity is limited to a pH level above 5.0. Supplemental microbial enzymes are active in the pH range of 3.0 to 9.0 and can facilitate the utilization of a much larger amount of protein, carbohydrates, and fat before hydrochloride is secreted in sufficient amounts to neutralize their activity.

Supplemental enzymes of animal origin are destroyed by the low pH within the stomach unless they are enterically coated. Yet, this coating can prevent the dissolution of the enzymes and prevent any digestive benefit. Studies have shown that non-enteric coated products can be more effective than coated products.

Furthermore, animal-based enzymes function only at the narrow pH ranges found at specific anatomical sites. Pepsin is only active in the highly acidic environment of the active stomach. Pancreatin, trypsin, and chymotrypsin are only active in the alkalinity of the duodenum. Supplemental microbial enzymes exhibit activity throughout the entire digestive process. Therefore, microbial enzymes can play a significant role in improving food nutrient utilization.

Another advantage of microbial enzymes is the variety of enzymes available for supplementation. While pancreatin offers only protease, lipase, and amylase activities, microbial enzymes offer protease, peptidase, lipase, amylase, glucoamylase, invertase, malt diastase, lactase, alpha-galactosidase, cellulase, hemicellulase, pectinase, and phytase activities. Pancreatin is a pre-defined blend and the only alternatives are proportional increases in total activity that may not be necessary. Customization and flexibility to match the appropriate enzymes to the diet is another strength of supplemental microbial enzymes.

Yet, another advantage of microbial enzymes is that they are animal-friendly. These enzymes are vegetarian and cruelty-free.


What is Fibrin?

Fibrin is an insoluble protein that acts as a first responder whenever your body is injured. Fibrin is normally present in an inactive form known as fibrinogen. Fibrinogen is soluble in water and is found in high concentrations in the blood, where it waits until needed to form a clot. When given the signal, fibrinogen is converted to fibrin, which then assembles into an extended network of fibers.

One of your body’s first responses to pain, injury, or trauma is to produce fibrin. Part of this process includes fibrin molecules rushing to the scene. These fibrinogen molecules are shaped like a rod and come together to interlace and form a thin mesh around a wound. It is within this mesh that the healing process occurs.

Let’s look at an example; when you cut yourself, you bleed, but the bleeding usually stops fairly soon. Blood has a built-in emergency repair system that quickly blocks any damage to the circulatory system, creating a temporary patch that allows time for more permanent repairs. There are three basic mechanisms in the overall healing process. First, platelets (small fragments of blood cells that circulate in the blood) clump at the site of the wound, forming a weak plug. Second, neighboring blood vessels constrict, reducing the amount of blood flowing into the area. Finally, the protein Fibrin assembles into a tough network that clots the blood and forms an insoluble blockage. Together, these methods stop the loss of blood and create a sturdy scab to protect the area as you heal.

This mesh is critical for trapping the platelets and red blood cells needed to form blood clots. Without fibrin, even small wounds would just keep bleeding. Fibrin mesh is the base material for clots, scabs, scars, and eventual healthy skin.

When we are young, and our internal systems are vibrant and working well, the fibrin rushed to the injured site is returned to our body as we’re healing. After a few days of repairs, our system sends in a second group of enzymes to dissolve the excess fibrin and leave our muscles, nerves, and blood vessels just as they were before the injury.

When our internal supply of systemic enzymes is plentiful, once fibrin is produced, it quickly dissolves and leaves the area of trauma. However, as we age, the body is less able to deplete fibrin and the potential exists for excess fibrin build up. It can impact how healthy and flexible our body stays as we age. Persistent pain, loss of flexibility, and inflammation may be the result of excessive fibrin levels.

Unfortunately, we all age, and our bodies don’t produce the same levels of internal substances that we used to. Over time, as excess fibrin is not removed, the fibrin molecules thicken and stiffen, forming scar tissue masses that can block blood vessels, interfere with muscle function, and lead to inflammation

Excess scar tissue restricts blood flow and oxygen throughout your body, slowing down your healing process and keeping you in pain longer. As the scar tissue thickens, it reduces your range of motion and contributes to chronic pain.

Proteolytic enzymes are responsible for breaking down protein molecules. They can have the ability to react with fibrin masses and reduce their size and area.

For most people, a regular diet alone won’t overcome the natural result of reduced enzyme production from aging. For many of us, the best naturally occurring proteolytic enzyme food sources are not a significant part of our normal dietary intake. Proteolytic enzymes from plant sources like pineapple stems or papaya, do exist, but are not a significant source of enzymes from our diet.*

What are Biofilms?

Biofilms are a collective of one or more types of microorganisms that can grow on many different surfaces, including living tissue.

Microorganisms that form Biofilms include bacteria, fungi, and protists. One common example of a Biofilm is dental plaque, a slimy buildup of bacteria that forms on the surfaces of teeth. Biofilms can also be found within arteries and body tissue.

According to the National Institutes of Health:

A Biofilm is an assemblage of microbial cells that is associated with a surface and enclosed in a matrix of primarily polysaccharide material. Noncellular materials such as mineral crystals, corrosion particles, clay or silt particles, or blood components, depending on the environment in which the biofilm has developed, may also be found in the Biofilm matrix. Biofilm-associated organisms also differ from their planktonic (freely suspended) counterparts with respect to the genes that are transcribed. Biofilms may form on a wide variety of surfaces, including living tissues, medical devices, or natural aquatic systems.

How Do Biofilms Develop?

According to the Center for Biofilm Engineering at Montana State University, Biofilms take shape when bacteria in moist environments adhere to surfaces by secreting a glue-like substance. This occurs on non-living materials such as metal and plastic (e.g. the slimy film coating a sink drain or shower curtain), but they also form on living tissues.

Think of Biofilms inside the body as microbial bomb shelters. A construction of sugars and proteins, biofilms are designed to protect organisms from the onslaught of your immune system and any antimicrobial compounds you take to get rid of the living inhabitants.

If left to accumulate, the matrix that anchors Biofilms to your organ systems gets stronger over time and begins to attract other microbes and toxins into the protective layer.

What starts as a small gang of pathogenic bacteria can become the breeding ground for invasive fungi, parasites, and viruses. An established Biofilm can also provide an unhealthy environment for various toxins.

Organisms growing and reproducing within the Biofilm matrix can become more resistant to antibiotics and the immune system. Normally, a healthy immune system seeks out to destroy single pathogens with an arsenal of immune secretions. But a protected biological mass under a Biofilm may not signal the immune system of a possible threat. Such an attack waged by immune cells must penetrate through the tough Biofilm shield to target the pathogens.

How Can You Reduce Biofilms?

Research indicates that taking Systemic Enzymes may have the effect of breaking apart the sugars and proteins that act as binding agents and form Biofilm. The ingredients found in Trevinol, are believed to have the capacity to break down these agents and play a role in reducing Biofilms.

When you take digestive enzymes with meals, enzymes speed up the dismantling of food in your stomach. When you take certain other enzymes between meals on an empty stomach, they can spend time on systemic healing tasks such as inhibiting inflammation and destroying the protein-based protective shields around bacteria, viruses, yeast, fungi, and food allergens.

While many enzymes don’t survive in acidic environments, Trevinol uses enteric-coated capsules to avoid this potential problem. Taking systemic enzymes between meals when the stomach is more alkaline, further reduces their chance of being destroyed as they pass through the stomach and move on to the intestines for absorption.

Many people may not be familiar with Biofilms. But most people can benefit from cleansing Biofilms within their body. There may be meaningful benefits from taking protein-digesting ("proteolytic") enzymes such as Proteases, Nattokinase, Bromelain, and Papain.

Some potential benefits include:

Healthy Inflammation Response
Cleanses the Blood
Dissolving Formation of Fibrin (a protein linked to inflammation and blood clots)
Support of the Immune System
Dissolving Scar tissue

What is Lactospore?

“Probiotics are live bacteria that line your digestive tract, often called “good” or “helpful” bacteria because of their overall supportive role in helping to restore the composition of the gut microbiome—by creating an ideal environment and introducing beneficial functions like nutrient absorption, healing of digestive issues, supporting overall brain health, help fight certain allergic conditions and infections.” Sabina Corporation.

Study: Shelf Stable Probiotic LactoSpore May Improve Cholesterol Levels.

Findings endorse LactoSpore® as a dietary ingredient for the management of hypercholesterolemia. LactoSpore is a key ingredient in the Trevinol® Blend.

New research published in a peer-reviewed journal International Journal of Food Science & Technology found that Sabinsa’s probiotic strain Bacillus coagulans MTCC 5856 (LactoSpore) could be effective in managing hypercholesterolemia and may reduce the incidence of coronary heart disease.

“This is particularly significant because higher than normal serum cholesterol levels is the leading cause of coronary heart disease and other disabilities,” said Dr. Muhammed Majeed, founder of Sabinsa. Coronary heart disease is one of the foremost causes of death and other disabilities in developing countries and in the western world. The World Health Organization estimates that nearly 23 million people will be affected by coronary heart disease and that it will become the major cause of death by 2030.

This study investigated the in vitro cholesterol-lowering activity of LactoSpore. This probiotic strain was found to be positive for bile salt hydrolase enzyme activity, which is an important criteria and biomarker for the selection of probiotic strain adjuncts to manage hypercholesterolemia.

The study also reported that LactoSpore® was not only effective in reducing cholesterol in culture media but also in cholesterol-rich foods, such as egg yolk (39.79%), chicken liver (45.44%), and butter (49.51%) when incubated in conditions mimicking the in vivo environment.

The study concluded that LactoSpore reduces cholesterol levels in multitudinous ways, which endorses its application in functional food formulations and as a dietary ingredient for the management of hypercholesterolemia. It was suggested that use could reduce the incidence of coronary heart disease and other related disabilities.

Although further studies may be needed, the findings provide clear evidence of the effectiveness of the probiotic strain LactoSpore in the nutritional treatment of diet-induced hypercholesterolemia.


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