Lithium Orotate


Lithium orotate is a nutritional supplement that encourages a balanced mood and a healthy stress response. Lithium orotate is low-dose natural lithium (mineral) bound to orotic acid for exceptional bioavailability. † 100 enteric-coated tablets. †Results may vary.

Lithium Orotate

 Professional Formulas

What Is Lithium Orotate?

The lithium in lithium orotate is a naturally-occuring trace mineral with a long history of therapeutic use for supporting a healthy mood and a healthy stress response. When bound to orotic acid as lithium orotate, the result is functional nutrition for a healthy mood, healthy stress response, and healthy cognitive function. Each enteric-coated tablet provides 4.6 mg of elemental lithium.

Lithium orotate (the lithium salt of orotic acid) is 20 times more bio-active than other lithium salts, allowing a reduction in dosage which greatly reduces the likelihood and severity of potential side effects.

What Are Orotates?

Orotates are organic "carriers" that transports the natural Lithium exactly where it needs to be delivered so that it reaches the blood cells of the brain. This is where chemical imbalances occur. When organic Lithium is combined with Orotate, it is reported to be many times more effective than the chemical, inorganic Lithium and to have NO side effects.

Dr. Hans Nieper's theoretical explanations of the mechanisms behind his stunning success in the clinical application of sophisticated mineral transporters rely heavily on the concept of the fixed pore mechanism of active transport. The theory called "fixed pore mechanism" suggests that a carrier molecule, in this case Orotic Acid (B-13), is attached to the compound being transported. This research has lead to the creation of mineral chelates called orotic acid chelates, or orotates which offers a 20 fold increase in utilizing minerals.

In his writings on lithium orotate, Dr. Hans Nieper stressed how the primary function of lithium was the restoration of the proper electrical membrane potential by removing excess sodium from the inside of the cell. In the orotate form he was able to obtain results using small dosages, about 7% of the synthetic carbonate form. He reported that 5 mg of lithium orotate are closely equivalent to 100 mg of the synthetic carbonate form.

According to Dr. Nieper, the lithium orotate releases lithium ions at the lysosomal membranes (structures within the cells), and withdraws sodium from them. The net result is a stabilization of the lysosomal membrane. If lysosomal enzymes are released within the cell they cause a cascade of destruction that leads to cellular death. The stabilization of the lysosomal membranes within the cell is a vitally important part of maintaining cellular health.

In 1998 a break-through discovery was reported by researchers from the National Institutes of Health in Bethesda, Maryland. They discovered that neurons (from rat brains) that were treated with lithium for six to seven days were completely protected from glutamate toxicity. It seems that the lithium attached itself to the receptors where the glutamate normally docks. This prevented the hyperactivity and resultant overload of calcium into the cell.

This exciting new understanding of one of lithium's protective actions against neurotoxicity from excessive glutamate opens the doorway for increased utilization of low dose lithium orotate. It appears that both lithium and B12 (in the methylcobalamin form) have a very beneficial role to play in protecting the human brain from this destructive neurotoxic process.

Health Benefits of Lithium Orotate

  • Supports a healthy mood
  • Normal response to stress and anxiety
  • May help with Chemical Dependency
  • Help with Fibromyalgia symptoms
  • May help with Gout symptoms
  • May help with Cluster Headaches
  • Healthy response to brain aging
  • Promotes calmness and clarity
  • Boosts healthy mental alertness and memory
  • Boosts healthy neurotransmitter function
  • Supports the brain's pathways of detoxification
  • Anti-edema

Clinical research tells us that lithium is active in the following functions:

  • Protects brain cells from toxicity
  • Promotes brain cell regeneration
  • Increases gray matter of the brain
  • Regulates brain neurotransmitters
  • Supports healthy mood balance
  • Improves blood sugar metabolism

The following are excerpts and quotes from an article by Ward Dean, M.D. and Jim English. Please consult with your healthcare professional before using Lithium Orotate. 

The orotic form of lithium is transported directly to the intracellular membranes of mitochondrial, lysosomes and the glia cells. It stabilizes the lysosomal membranes and prevents the enzyme reactions that are responsible for sodium depletion and dehydration effects of other lithium salts making it a far superior source than the pharmaceutical forms of lithium and far safer too. Lithium protects against the shrinkage of the prefrontal cortex and the reductions in glial cell density, which are otherwise seen in bipolar depression. It may provide the growth-promoting support necessary to restore, enhance, and maintain normal synaptic connectivity.

Lithium has been found to be one of the most effective treatments for manic-depressive illness (bi-polar disorder). Normally these patients are given antidepressant drugs which are known to deplete body stores of L-carnitine and Taurine. These amino acids should be supplemented using several grams daily to ameliorate the adverse side effects of these drugs.

Of course it would be better to avoid these drugs all together and that is what Lithium Orotate enables many to accomplish. This is an important consideration, especially when the therapeutic dose of lithium orotate for cases of severe depression is 150 mg/day (1-2 tablets), compared to 900-1800 mg of the prescription forms. In this dosage range, there are no adverse lithium side effects and no need for blood monitoring.


†Results may vary.

Net Content: 100 enteric-coated tablets

Lithium (as lithium orotate) 120 mg (provides 4.8 mg of elemental lithium)

Other Ingredients:  Magnesium carbonate, Avicel, Duratex, Pure Food Glaze, Compritol, Ac-Di-Sol, Plasdone, Magnesium Stearate.

Contains no yeast, corn, starch, fructose, lactose, artificial coloring or flavoring.


† Results may vary.

Take 1 tablet 2-3 times daily with meals or as directed by your healthcare professional.

Lithium Safety

Based on research, Lithium carbonate (prescription lithium) should not be taken if you: require a prescription drug, have Renal disease, have Cardiovascular disease, are severely Ill, suffer from dehydration, take Diuretics, take ACE inhibitors, take beta-blockers or other anti-hypertension drugs, take insulin.

Although the warnings above appear to be true for pharmaceutical lithium compounds only and not for a modest serving of lithium orotate, it’s always wise to consult with a knowledgeable health care professional for anyone contemplating using lithium orotate concurrently with any of these medications.

If you are already taking prescription lithium you should not under any circumstances add lithium orotate to your regimen as you may already be at or near a toxic level of lithium within your bloodstream.

† Results may vary.

mineral-transport-cell-theory -dr-nieper

  1. Dr. Nieper advised and rid the ailing former president Ronald Reagan of his cancer. He treated thousands of everyday people like you and me. Nancy Sinatra lavished praise on this great German physician: "He is a fabulous person, a recognized scientist, a marvelous doctor." His patients both loved and respected him.
  2. Dr. Nieper is reported to have one of the highest cure rates for cancer in the medical world.
  3. His success with Depression, Migraines and Bi-polar disorder using Lithium Orotate is unsurpassed.
  4. He developed natural medications which were reviewed and approved by the German Government for cancer and the only official MS treatment.
  5. One of his most important precepts was: "Cancer cannot be treated as a local disease. Cancer infests the entire body; therefore, the entire body must be strengthened." This is why he treated disorders at the cellular level with non-toxic substances.
  6. Dr. Nieper's patients included many world stars, royalty and politicians, including Ronald Reagan, Princess Caroline of Monaco, Anthony Quinn, John Wayne and Yul Brynner.
  7. He is the man who invented Mineral Carriers, the 4 different substances used to transport minerals to the cellular level. These are undoubtedly the most assimiable form of minerals that people can digest in dietary supplement form.
  8. Dr. Nieper called 2-AEP his "Anti-Aging Formula". In studies done with 2-AEP over a 4 year period, those treated with 2-AEP (approximately 4,000) did not age as rapidly as those not treated. The appearance and elasticity of the skin, as well as the organs' functions "did not appear to age almost at all." Furthermore, Dr. Nieper points out that "none got cancer." 2-AEP has been approved by the German Health Authority (FDA equivalent) as an official treatment for Multiple Sclerosis. 2-AEP strengthens the cell walls. Their electro-static energy increases to defend against diseases and to keep "free-radicals" from entering and infecting our healthy cells.
  9. Dr. Nieper is known for his incredible success with the products he discovered, upholding health and longevity:
    • Lithium Orotate for treating Depression, Mania and Bi-polar disorders.
    • Bromelain for its deshielding properties in cancer therapy.
    • Gene repair substances like Iridodial and Dionaea Muscipula (Venus Fly Trap) to attack unhealthy cells and viruses.
    • Unique transporting capabilities of mineral carriers such as the 2-AEP, Aspartates, Arginates and Orotates.
    • The unsurpassed Anti-Ageing success with 2-AEP.
    • Treatment of MS with calcium AEP.
    • The ability to naturally produce DHEA in the body through squalene and buffered vitamin C
  • Dziedzicka-Wasylewska M, Mackowiak M, Fijat K, Wedzony K. Adaptive changes in the rat dopaminergic transmission following repeated lithium administration. J Neural Transm Gen Sect. 1996;103(7):765-76.
  • Perez-Cruet J, Tagliamonte A, Tagliamonte P, Gessa GL. Stimulation of serotonin synthesis by lithium. J Pharmacol Exp Ther. 1971;178(2):325-30.
  • Rybakowski JK. Antiviral and immunomodulatory effect of lithium. Pharmacopsychiatry. 2000;33(5):159-64.
  • Cernescu C, Popescu L, Constantinescu S, Cernescu S. Antiviral effect of lithium chloride. Virologie. 1988;39(2):93-101.
  • Lieb J. Lithium and immune function. Med Hypotheses. 1987;23(1):73-93.
  • Tabata I, Schluter J, Gulve EA, Holloszy JO. Lithium increases susceptibility of muscle glucose transport to stimulation by various agents. Diabetes. 1994;43(7):903-7.
  • Hu M, Wu H, Chao C. Assisting effects of lithium on hypoglycemic treatment in patients with diabetes. Biol Trace Elem Res. 1997;60(1-2):131-7.
  • Nieper HA. The clinical applications of lithium orotate. A two years study. Agressologie. 1973;14(6):407-11. Available as article #CM12 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
  • Nieper HA. Revolution in Technology, Medicine and Society. Oldenburg, Germany: MIT Verlag; 1985. Available from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
  • Sartori HE. Lithium orotate in the treatment of alcoholism and related conditions. Alcohol. 1986;3(2):97-100.
  • Lanphier, NP, CN, CH, HHP Loretta. Benefits of Lithium Orotate.
  • Orotates and Mineral Transporters - Fact or Fiction. Ed Sharpe.

Recent Lithium Research

Evidence suggests that people with mania or depression may lose brain cells. Lithium may thwart that cell death. A study by Chuang and his colleagues reveals that lithium protects brain cells from being stimulated to death by glutamate, one of the many chemicals that transmit messages in the brain. Their new data suggest that lithium may calm overexcited areas of the brain or, more provocatively, preserve the life of brain (glial) cells whose presence guards against manic depression. It was also reported that it does take a week or two for the neuro-protective effects of lithium to fully take place.

Lithium supplementation shields neurons and intact brains alike against insults as wide-ranging as excessive doses of anticonvulsant medications, deprival of growth factors or essential electrolytes, the Alzheimer’s protein amyloid, and neurotoxins like oubain, quinolinic acid, and MPP+. Lithium supplements decrease the number of brain cells killed by experimental strokes by 40%, and help the animals to recover their balance and motility more quickly. Remarkably, most of these benefits can be gained even after the model stroke is over. Lithium supplements also aid brain regeneration in animal models of Huntington’s disease.

Lithium Orotate provides defense against excitotoxicity

(the frying of brain cells by over stimulation). It does this through precision modulating of the N-methyl-D-aspartate (NMA) receptor’s response to the stimulatory neurotransmitter glutamate. Glutamate binds to a cell surface protein of the NMDA receptors when it excites a cell. Normally, activation of the NMDA receptor by glutamate triggers an influx of calcium ions, setting off a signaling cascade inside cells. However, cells treated with lithium let in far less calcium when exposed to glutamate. Lithium has a “push/pull” effect on glutamate raising its levels when they are too low and lowering them when they are too high by modulating it reuptake. This balancing act helps to prevent both excessive stimulation (which kills brain cells and inadequate activation of the NMDA receptor which interferes with normal activation and function of nerve cells needed for mood and memory. In people with manic depression, lithium may correct a dysfunction of the NMDA receptor by limiting calcium influx, speculates Chuang.

Lithium Orotate increases levels of the major neuroprotective protein bcl-2 in brain cells. Bcl-2 is a cell survival protein which inhibits cell death in response to a wide range of neurotoxins and cellular stressors, including large doses of cortisol (prednisone), ionizing radiation, free radicals, chemicals that deplete brain cells of the antioxidant reduced glutathione (GSH), and deprivation of crucial brain growth factors. Beyond its abilities to protect brain cells from toxic assault, it’s now emerging that lithium, acting through bcl-2, also helps to regenerate nerve cells, activating a genetic program (the ERK/MAP kinase pathway) that stimulates the growth of new axons and promoting the sprouting of new neurites (the branching “tips” of nerve cells which bridge the gap between neurons).

And perhaps most excitingly of all, lithium inhibits the activity GSK-3, an enzyme, which promotes the formation of the key pathological features of brains under assault by Alzheimer’s disease. GSK-3 is involved in forming the ‘tangles’ that characterize the brains of Alzheimer’s patients. So damping down the activity of GSK-3 would be expected to reduce tangle formation. And in animals given a gene that causes them to overproduce the precursor to the brain-wrecking amyloid protein, lithium supplements interfere with the formation of amyloid peptides and prevent plaque formation. This has led to the recommendation that the use of lithium in “experimental trials aimed to ameliorate neurodegeneration in Alzheimer’s disease should be considered.”


Lithium Orotatesupplementation increases levels of N-acetylaspartate (a marker of brain cell viability and function). But more than that: Researchers have documented increases in grey matter in humans taking lithium supplements for just four weeks – with the largest increases occurring in the hippocampus, a region of the brain crucial for moving short-term memories into long-term storage, and which is the first and most severely-hit area of the brain in victims of Alzheimer’s disease. Importantly, these selective effects were specifically observed in areas where atrophy had previously occurred.

From Dr. Nieper: Lithium Orotates Improves Liver Function

Dr. Nieper points out that “it is not unusual for orthodox medicine to be quite helpless in the treatment of chronic liver ailments, especially chronic immunological liver inflammation. In these chronic liver inflammations…the continued release of lysosomal enzymes plays a role. These are very aggressive, cell-destroying enzymes released by little bubbles in the cell plasma known as lysosomes. These lysosomes exist not so much in the liver cells themselves, as the cells of the liver’s supportive connective tissue. One could attempt to seal the walls of these lysosomal bubbles, to prevent the release of these aggressive enzymes. In fact, a possibility for this exists. It is feasible to release calcium at the lysosome membranes by specifically transporting it there. This can be achieved by means of the special compound, calcium orotate.

In addition, the sodium content in these bubbles – and especially in their walls – must be kept as low as possible, i.e., sodium must be specifically displaced. This can be done by transporting sodium-displacing lithium to these sites using lithium-orotate.Another possibility for removing part of the sodium from the liver is given by the use of Taurine. This is a substance produced by large saltwater fish to remain “sweet” inside, and not as salty as the surrounding seawater.” (Please note any free form amino acid, such as Taurine, must be taken with Vitamin B6 in order to be absorbed efficiently. Why the manufacturers, many of whom know this don’t put B6 into their products confounds me.)

The famous mineral springs of Europe, such as Vichy in France, all have high lithium waters and are in high demand for liver cures. One of its mechanisms of action is displacing sodium with lithium in liver cells. This has the effect of softening the liver and facilitating other medicines into the liver. This form of lithium does not build-up in the blood to dangerous levels as the carbonate, citrate, and acetate forms do. This is simply because it’s absorbed by the cells much more readily than other forms.

Lithium orotate is often used with calcium orotate for high liver enzymes.  For normal applications Dr. Nieper recommended 1 tablet 2 – 3x daily. Occasionally some will experience more fatigue, if so lower the dose.

† Results may vary.

How much elemental lithium is in lithium orotate?

Each capsule provides 10 milligrams (mg) of elemental lithium.

Does this product contain gluten?

This product is gluten-free.

Does this product contain genetically modified ingredients (GMOs)?

Lithium Orotate does not contain GMOs.

Why are the tablets enteric-coated?

Lithium absorption takes place primarily in the small intestine, regardless of the source or type of the lithium. However, for the most effective absorption rate, the supplement must be formulated and packaged correctly. This means that the natural lithium must be able to reach the small intestine intact. In order to accomplish this with a non-enteric coated capsule, at least 2x the amount must be taken in order to get the same effect as one-two tablets of Dr. Nieper's specially formulated lithium orotate.

  • Dr.Neiper found that mineral transporters work better, when each granule is enterically coated by a micro-vortex process, which ensures intact passage of the compound through the acidic environment of the stomach. Other products who don't utilize this patented process end up providing "free" minerals and amino acids, which aren't targeted (tissue specific).
  • Micro-vortex coating of mineral transporters is when individual granules are enterically coated with a soluable compound which resists the stomach acid and yet is readily dissolved in the alkaline environment of the small intestine.
  • Micro-vortex enteric coating delivers the mineral transporter into the small intestine in tact where it is moved into the blood stream in tact, where the transporters enter the cells and the minerals are released at specific cell sites.

Some manufacturers of lithium orotate do not believe that enteric coating is necessary and that the enteric-coating that Dr. Nieper used was for marketing purposes. However, people who actually knew Dr. Nieper disagree with this. After speaking, several years ago, with a person who worked with Dr. Nieper, this person affirmed that Dr. Nieper insisted on the enteric-coating (he called it a micro-vortex process) in order to make sure that the mineral orotate actually reached the small intestine intact so that effective and efficient absorption would take place.


How long will a bottle last?

Each bottle of Lithium Orotate contains 100 enteric-coated tablets and will last two months.

How does lithium orotate work?

Lithium supports the health and function of the hippocampus and interacts with several neurotransmitters and receptors in the central nervous system to promote mental focus and memory.

Can elemental lithium affect kidney function?

Long-term, large servings of any type of lithium can affect kidney function; however this is usually seen in people with pre-existing kidney issues. Lithium and sodium have similar effects on nerve cells but because it is smaller in size, lithium displaces sodium in the brain. The excessive sodium has to be excreted through the kidneys, which can stress the kidneys. It is very important to stay hydrated when taking lithium orotate.

Can lithium orotate affect the thyroid?

Long-term, large servings of any form of lithium can affect thyroid function, which is usually reversible upon discontinuing use. If you take Lithium Orotate as directed, you will not get a large serving, and should not have an issue. However, always be sure to check with your healthcare provider if you have any thyroid condition.

Should I get regular testing while taking lithium orotate?

Follow the advice of your healthcare practitioner. Once a year kidney function and thyroid function tests should be performed if you have known thyroid or kidney conditions or as recommended.

Can I drink alcohol while taking lithium orotate?

Alcohol should be avoided while taking lithium orotate.

Does lithium orotate have to be taken every day?

Most people see the greatest benefit by taking lithium orotate every day as directed.

Can children take lithium orotate?

Lithium orotate is not recommended for children unless supervised by a healthcare practitioner.

Can pregnant or nursing women take lithium orotate?

Lithium orotate is not recommended for pregnant or nursing women.

Can lithium orotate be given to pets?

Lithium orotate is not recommended for pets.

Are any health conditions not compatible with lithium orotate?

People with severe thyroid issues or kidney disease should not take lithium orotate. Be sure to talk with your healthcare provider if you have any health concerns.

Does lithium orotate interact with other nutritional supplements or prescription drugs?

Lithium orotate can interact with a number of prescription medications, including antidepressants, blood pressure medication, anti seizure medications, NSAIDs, and diuretics. If you’re taking these, or any other prescription medication, consult your healthcare practitioner before adding any form of lithium to your routine. Additionally, lithium orotate can interact with some herbal and nutritional supplements, including, but not limited to, St. John’s wort, GABA, tryptophan, 5-HTP, and other supplements that affect neurotransmitters.

What’s the best time to take lithium orotate?

Lithium orotate may be taken at any time throughout the day. Many people report that taking it after meals is most beneficial. If taken on an empty stomach, lithium orotate may cause mild stomach upset in some individuals.

Are there any special instructions when taking lithium orotate?

Stay well-hydrated and drink plenty of purified water when taking lithium.

How long does it take notice the benefits of lithium orotate?

Results vary but some people report feeling benefits in under an hour, while others don’t notice benefits for a few weeks.


† Results may vary.


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