Oasis Serene Progesterone Cream

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Oasis Serene progesterone cream is a combination of natural ingredients including organic avocado oil, and organic cold-pressed whole-leaf aloe vera which softens, smooths and refreshes the skin. Oasis Serene utilizes Mexican Wild Yam Root, a natural source of progesterone prepared according to the USP, added to select antioxidants like Camu Camu (vitamin C), along with natural Vitamin E, Vitamin A and Vitamin B6 making this natural rejuvenating creme a best friend to both women and men.† †Results may vary.

What is Oasis Serene™ Progesterone Cream?

Oasis Serene™ rejuvenating natural progesterone cream is a combination of natural ingredients including organic avocado oil, and organic cold-pressed whole-leaf aloe vera which softens, smooths and rejuvenates the skin. Oasis Serene™ progesterone cream utilizes Mexican Wild Yam Root, a natural source of progesterone prepared according to the USP, added to select antioxidants like Camu Camu (natural vitamin C), along with natural vitamin E, Vitamin A and Vitamin B6 making this natural anti-aging and rejuvenating crème a best friend to both women and men. Using just 1/8 teaspoon of Oasis Serene™ will bring you all the benefits of a high quality progesterone crème. Unlike other creams that encourage over-use, for Oasis Serene™ a very small amount really does go a long way.

Facts About Natural Progesterone Cream

  1. Stimulates osteoclast bone building (osteoporosis reversal)
  2. Helps use fat for energy
  3. Natural diuretic
  4. Natural antidepressant
  5. Restores sex drive (libido)
  6. Normalizes zinc and copper levels
  7. Facilitates thyroid hormone action
  8. Prevents endometrial and breast cancer
  9. Protects against fibrocystic breasts
  10. Normalizes blood sugar levels
  11. Normalizes blood clotting
  12. Restores proper oxygen cell levels
  13. Normalizes menstrual cycles
  14. Supports healthy hormone balance

Why Oasis Serene Natural Progesterone Cream is the BEST Choice

  • Made with organic ingredients. Contains vitamin E and Rosemary Essential Oil as natural preservatives. Does not included unneeded or estrogenic herbs.
  • Made in small batches to insure that your superb natural progesterone cream reaches you in the freshest condition possible. Oasis Serene is made “at need” to ensure potency. Does not sit in a warehouse. All the ingredients are processed and certified in the US and made in a FDA inspected facilitly.
  • Independent laboratory certified for the quality of USP progesterone content of 750 mg/oz. Many "popular creams" sold today contain little or no USP progesterone, or at best, have inconsistent levels of progesterone.
  • Made from USP (United States Pharmacopeia) progesterone, not wild yam extract. No published studies conclude that yam increases progesterone levels in animals or humans. While the diosgenin molecule from wild yams can be converted to a progesterone molecule in the laboratory, it cannot do so in the human body. Unconverted diosgenin is a cheap way to produce a progesterone cream, and according to Dr. Lee does not work well. It is important to insist upon USP progesterone, not uncertified cheap ingredients made in some foreign countries. USP Web Site.
  • Free of Methyl Paraben, Propyl Paraben, Butyl Paraben or any of the related Parabens or estrogenic herbs. Those ingredients are used as preservatives and contribute to estrogen dominance. Paraben-class preservatives also can irritate the skin.
  • Free of ethoxylated wetting agents, such as PEG 8 Stearate, PEG 100 Stearate, Polyethylene Glycol, Polysorbate 60, or Polysorbate 80, which may be contaminated with 1,4-dioxane, a known carcinogen.
  • Free of mineral oil. Mineral oil blocks the absorption of natural (bioidentical) progesterone.
  • Free of Stearal Konium Chloride, an emulsifier.
  • Does not use pump bottles. Progesterone, or any other sex hormone, does not dissolve in lotion or cream. It is suspended. Because of this it is possible to have “migration” which causes the progesterone to “sit on the bottom” of the bottle. A concern with pump bottles is that because of this migration you may get a “hit” of progesterone at the beginning and then absolutely none at the end of the bottle. Oasis Serene is packaged so that you can use the exact amount to fit your particular needs.
  • Transdermal is Best. Oral (pill form) progesterone must be metabolized by the liver which means you would need at least 50x’s more progesterone to get the same effect that you get from using a transdermal progesterone cream. Why put your liver through extra processing? The concern with progesterone tinctures is that they must be taken throughout the day on a strict schedule in which many women are unable to follow. Transdermal means that it is rubbed into skin and goes directly into the bloodstream and begins to hit the receptor sites immediately.
  • GMO-free. No animal testing. Gluten-Free. Made in the USA.
  • Botanically based.
  • Fast drying and absorbing.
  • Non-greasy and Non-clogging.
  • Fragrance-free.
  • pH balanced.
  • Contains no common irritants or artificial colors.
  • Formulated by Naturopathic Practitioner, Loretta Lanphier, for those wanting a non-toxic progesterone cream.

Progesterone Cream as an Anti-Aging Cream

According to a 2005 study done by the Division of Special and Environmental Dermatology at the Medical University of Vienna, a cream containing progesterone USP can have positive effects on the skin of peri-menopausal and postmenopausal women. The study was done over a 16 week period on 40 subjects. At the end of the study, the application of two percent progesterone USP cream had a noticeable anti-aging effect on the appearance of the participant's skin. The skin of the subjects showed an improvement in the appearance of elasticity and firmness after daily application of the cream. (Effects and side-effects of 2% progesterone 3am on the skin: results from a double-blind, vehicle-controlled, randomized study)

Reasons to Use Oasis Serene™ Progesterone Cream Cosmetically

  • Helps with dry skin associated with normal aging process.
  • Helps to improve the skin's appearance by softening wrinkles associated with normal aging process.
  • Helps to moisturize dry skin.
  • Helps to hydrate the skin.
  • Helps to improve skin's appearance of elasticity and firmness.
  • Botanically based.
  • Includes organic ingredients.
  • Fast drying and absorbing.
  • Non-greasy and Non-clogging.
  • Fragrance-free.
  • GMO-free. No animal testing. Gluten-Free. Made in the USA.
  • Contains no harmful chemicals.
  • pH balanced.
  • Contains no common irritants or artificial colors.
  • Contains no parabens, mineral oil, or petroleum ingredients.
  • No pre-measured packaging. Packaged so that you can use the exact amount to fit your particular needs.
  • Formulated by Naturopathic Practitioner, Loretta Lanphier, for those wanting a non-toxic progesterone cream.

†Results may vary.

Package - 2-ounce jar (BPA-free)

OASIS SERENE PROGESTERONE INGREDIENT LIST:

Purified Water, Cold-Pressed Whole-Leaf Aloe Vera (Aloe Barbadensis)*, Avocado Oil*, USP Progesterone (750 mg/oz), Vegetable Glycerin*, Rosmarinus Officinalis (Rosemary Extract)*, Milk Thistle Extract*, Vegetable Stearic Acid, Vitamin A (palmitate), Vitamin E (Natural Tocopherol), Vitamin B6, Camu Camu*, Grape Seed Extract*

*Certified Organic Ingredient

WARNING

Suggested Use

Rub on clean skin morning & night. Apply to thin skin areas where blood vessels can be seen. Rotate application areas. Do not use for more than 3 weeks out of each month. You don't need to use more than a very small amount to see the beauty within this product. 1/8 tsp provides approximately 15.5 mg of progesterone USP. Contains approximately 750 mg of USP progesterone per ounce. Please measure for each application using a plastic measuring spoon.

CAUTION: Keep out of reach of children. If pregnant, nursing, trying to become pregnant consult a healthcare professional. If rash or redness occurs, discontinue use. Oasis Serene™ should not be used by anyone under the age of 18 unless directed by a knowledgeable healthcare practitioner. Store in cool, dry place. Expiration date located on bottom of jar.

Note: As with any product that is placed on the skin or in the body, it is the consumer's responsibility to research all product ingredients.

Natural Progesterone Research

It is often mistakenly said that there is no scientific or research reference material on the use of natural (bioidential) progesterone.  This is simply not true, as there exists plenty of information and data in peer-reviewed medical journals but these are simply often not quoted or known about widely enough.   The following is a list of some of the many articles from journals that are widely accepted by authorities to be legitimate and well researched.

Breast Cancer Res Treat 2007;101:125-134 - “Estradiol and progesterone demonstrated no increased risk of breast cancer. Synthetic estrogen (Premarin® ) and synthetic progestins (medroxyprogesterone and noresterone) all dramatically increased the risk of breast cancer. This was a ten year study of over 100,000 women, the largest and longest study to date comparing natural hormones to synthetic hormones”.

Fertility Sterility 2005 Dec;84(6):1589-601 - “The WHI trial had major design flaws that led to adverse conclusions about the positive effects of hormone therapy. The study included mostly older women that already had cardiovascular disease. The study utilized only medroxyprogesterone (Provera® which we know negates any beneficial effect of estrogen, rather than the bio identical hormone, progesterone”. Multiple other studies with estrogen started early in menopause demonstrate beneficial effects.”

American Family Physicians 2000;62: 1339-46. - “Due to the side effects of synthetic progestin’s, natural progesterone is preferred. Progesterone has proven bio-availability and no side effects making it the preferred hormone for menopause.

Obstetrics Gynecology 1989;73:606 - “Natural estrogen and natural progesterone offer substantial clinical benefit over the synthetic hormones and should be the agents of choice for menopause.”

Maturitas 2003 Dec;46(1):555-58 – “Progesterone reduces proliferation of breast cancer cells and induces cellular apoptosis (kills breast cancer cells)

Japan Journal of Cancer Research 1985June;76:699-04. American Family Physicians: 2000;62(8):1839. – “Mammary tumor stimulation was reduced both by progesterone and Tamoxifen, more so by progesterone by Tamoxifen which is the drug of choice to treat cancer.”

Mayo Clinic, Women’s HealthSource: August, 1999, pg 3. – “The multitude of side effects associated with the synthetic analogues called progestins has stimulated an interest in natural progesterone. Natural progesterone is obtained primarily from plant sources. Natural progesterone has improved bioavailability and fewer side effects when compared with synthetic progestins. Natural progesterone has not been shown to affect mood or cholesterol levels. The synthetic progestins differ from the natural progesterone since they cause fluid retention, abnormal increase in cholesterol, headaches, mood disturbance, depression, and are frequently a cause of discontinuation of hormone therapy”.

Journal of Women’s Health Gender-based Medicine: 2000;9(4):381-7. – “The side effects of the synthetics include bloating, nausea, and depression were eliminated by using natural progesterone. In fact, unexpected improvement in the feeling of well-being was observed when natural progesterone was used.”

Endocrine Reviews: 28(4): 387 – 439 – “Progesterone has metabolic and hepatocellular effects (decreased insulin sensitivity, increased levels and activity of IGF-1, decreased levels of SHBG), which contrast the opposite effects induced by oral estrogen. Within the nervous system, the neuroprotective and promyelinating effects of progesterone are promising, not only for preventing but also for reversing age-dependent changes and dysfunctions. There is strong evidence that the ageing nervous system remains sensitive to the beneficial effects of progesterone, this may also extend to peripheral tissues including the breast, blood vessels and bones.”

PROGESTERONE

Breast Cancer Res Treat 2007;101:125-134 – “Estradiol and progesterone demonstrated no increased risk of breast cancer. Synthetic estrogen (Premarin®) and synthetic progestins (medroxyprogesterone and noresterone) all dramatically increased the risk of breast cancer. This was a ten year study of over 100,000 women, the largest and longest study to date comparing natural hormones to synthetic hormones”.

Fertility Sterility 2005 Dec;84(6):1589-601 – “The WHI trial had major design flaws that led to adverse conclusions about the positive effects of hormone therapy. The study included mostly older women that already had cardiovascular disease. The study utilized only medroxyprogesterone (Provera®) which we know negates any beneficial effect of estrogen, rather than the bio identical hormone, progesterone”. Multiple other studies with estrogen started early in menopause demonstrate beneficial effects.”

Female Patient 2001 Oct; 19-23. - “The main reason women discontinue HRT is due to side effects. Synthetic progestin’s (Provera®) cause may side effects: breast swelling and tenderness, uterine bleeding, depression and mood disturbance, weight gain, bloating and edema. Natural progesterone has no side effects.”

American Family Physicians 2000;62: 1339-46. - “Due to the side effects of synthetic progestin’s, natural progesterone is preferred. Progesterone has proven bio-availability and no side effects making it the preferred hormone for menopause.”

National Academy Science USA; 2003 Sept. 2;100(8):10506-11. – “Estrogen and progesterone are neuro-protective against cerebral damage. These beneficial effects were blocked by MPA (medroxyprogesterone).”

Obstetrics Gynecology 1989;73:606 - “Natural estrogen and natural progesterone offer substantial clinical benefit over the synthetic hormones and should be the agents of choice for menopause.”

Maturitas 2003 Dec;46(1):555-58 – “Progesterone reduces proliferation of breast cancer cells and induces cellular apoptosis”

American Family Physician 2000; 62:1939-46 - “Due to the side effects of synthetic progestin’s, natural progesterone is preferred. Progesterone has proven bioavailability and no side effects making it the preferred hormone for menopause.”

Obstetrics Gynecology 1989;73:606-611. - “Progesterone raises good HDL cholesterol, whereas MPA (Provera®), lowers good cholesterol. Progesterone increases estrogen beneficial effects whereas MPA reverses estrogen’s benefits. Progesterone has no side effects, whereas MPA has many”

Fertility Sterility 1998;69:963-69. - “Progesterone decreases Breast stimulation 400%, and down regulates breast receptor sites, thereby protecting against breast stimulation.”

Japan Journal of Cancer Research 1985June;76:699-04. - “Mammary tumor stimulation was reduced both by progesterone and Tamoxifen, more so by progesterone by Tamoxifen which is the drug of choice to treat cancer.”

American Family Physicians: 2000;62(8):1839. – The multitude of side effects associated with the synthetic analogues called progestins has stimulated an interest in natural progesterone. Natural progesterone is obtained primarily from plant sources. Natural progesterone has improved bioavailability and fewer side effects when compared with synthetic progestins.

Natural progesterone has not been shown to effect mood or cholesterol levels. The synthetic progestins differ from the natural progesterone since they cause fluid retention, abnormal increase in cholesterol, headaches, mood disturbance, depression, and are frequently a cause of discontinuation of hormone therapy. (Again adequate documentation in our literature of the protective benefits of natural progesterone without all the side effects of synthetics. It is very well supported in our medical literature, yet unfortunately unrecognized by most physicians.) ”

Mayo Clinic, Women’s HealthSource: August, 1999, pg 3. - Women prefer the use of natural progesterone over synthetic progestins. Natural progesterone made a difference in overall quality of life, menopausal symptoms, and satisfaction.

Natural progesterone is not associated with the abnormal metabolites from synthetic progestins. These abnormal metabolites are substances that are responsible for the side effects. Natural progesterone is the same substance you are making naturally, and therefore side effects are avoided. ”

American Family Physician: 1999;16(1):264. – “A better alternative. The side effects of the synthetics include bloating, nausea, and depression were eliminated by using natural progesterone. In fact, unexpected improvement in the feeling of well-being was observed when natural progesterone was used.”

Journal of Women’s Health Gender-based Medicine: 2000;9(4):381-7. - “A better alternative. The side effects of the synthetics include bloating, nausea, and depression were eliminated by using natural progesterone. In fact, unexpected improvement in the feeling of well-being was observed when natural progesterone was used.

When compared to the synthetic progestins, women using micronized, natural progesterone experienced significant improvement in symptoms without the side effects of the synthetics. The natural progesterone offers improvement in quality of life in comparison with the synthetic progestin.”

J Steroid Biochem Mol Biol. 2005 May -Progesterone, unlike synthetic progestins, does not have a detrimental effect on breast tissue. Synthetic progestins (MPA and 19-Nortestosterone derivatives) which have non-progesterone-like effects which can potentiate the proliferative actions of oestrogens.

Progesterone has metabolic and hepatocellular effects (decreased insulin sensitivity, increased levels and activity of IGF-1, decreased levels of SHBG), which contrast the opposite effects induced by oral oestrogen.”

Endocrine Reviews: 28(4): 387 – 439 - Within the nervous system, the neuroprotective and promyelinating effects of progesterone are promising, not only for preventing but also for reversing age-dependent changes and dysfunctions. There is strong evidence that the ageing nervous system remains sensitive to the beneficial effects of progesterone, this may also extend to peripheral tissues including the breast, blood vessels and bones.”

1. What is Prop 65?

Proposition 65, the Safe Drinking Water and Toxic Enforcement Act of 1986 , was enacted as a ballot initiative in the state of California in November of 1986. The Proposition was intended by its authors to protect California citizens and the State's drinking water sources from chemicals known to cause cancer, birth defects or other reproductive harm, and to inform citizens about exposures to such chemicals 1.

Proposition 65 requires the Governor to publish, at least annually, a list of chemicals "known to the state to cause cancer or reproductive toxicity" . Progesterone, as well as other human hormones, appear on this list 1. Set forth below is the information that formed the bases for the addition of progesterone to the Prop 65 list by the California Office of Environmental Health Hazard Assessment ("OEHHA").

Prop 65 and Progesterone - Perspective

In August of 2004, OEHHA published a document stating the rationale for the addition of Progesterone to the Prop 65 list 2. This document is a review of human, animal, and in vitro studies that used progesterone, synthetic progestins, and other progestagens (progesterone-like compounds). Experimental data from the use of all of these compounds were mixed together, along with data from studies using other steroid hormone derivatives (mainly synthetic estrogens) and many different methods of administration.

Although this review covered the existing scientific literature on progesterone and its many derivative compounds, there are many problems with the type of data analysis that was employed.

First, progesterone is endogenous to humans and necessary for bone and reproductive health while progestins and other synthetic progestagens are not. Progestins and progestagens are similar in molecular structure to progesterone, but when they bind to progesterone receptors, their effects are usually much stronger and more likely to cause abnormal physiologic responses 3, 4. Furthermore, the majority of the studies concerning the health effects of these progesterone derivatives involved combinations with synthetic estrogens 2-4.

There were very few studies mentioned in the 2004 document that used exclusively bio-identical progesterone (the kind found normally produced by humans as well as that used in progesterone creams), and those studies that did were at supra-physiologic doses (very high). The doses of progesterone ranged from 10-1000 times the dose usually recommended by manufacturers of progesterone creams 2, although in a few cases, the doses were closer to the recommended dosages.

The route of administration of progesterone is also at issue. All of the studies cited in the OEHHA document used either oral, injected, or suppository forms of hormones; none was conducted using transdermal creams. This is an important consideration because hormones absorbed through the skin are metabolized differently than hormones that are administered via other routes. 5, 6

Putting it Together

While the OEHHA Prop 65 reference document on progesterone 2 is a broad survey of the published scientific literature examining the potential effects of the pharmaceutical use of progesterone and its synthetic derivatives, it is not clear at all that these effects would be seen with the use of low-dose progesterone creams.

The OEHHA Prop 65 progesterone document evaluates a broad range of information regarding progesterone and synthetic materials that are not natural progesterone. The conclusion reached was not challenged, and it is on that basis that progesterone creams now carry the Prop 65 warning.

References:

1 California OEHHA Web Site: http://www.oehha.ca.gov/prop65/p65faq.html .

2 Reproductive and Cancer Hazard Assessment Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency (2004) Evidence on the developmental and Reproductive Toxicity of Progesterone.

3 Campagnoli C, Abba C, Ambroggio S, Peris C (2005) Pregnancy, progesterone and progestin in relation to breast cancer risk. J Steroid Biochem Mol Biol 97(5):441-450.

4Campagnoli C , Clavel-Chapelon F , Kaaks R , Peris C , Berrino F (2005) Progestins and progesterone in hormone replacement therapy and the risk of breast cancer. Steroid Biochem Mol Biol 2005 96(2):95-108.

5 de Lignieres B, Dennerstein L, Backstrom T (1995) Influence of route of administration on progesterone metabolism. Maturitas 21:251-257.

6 Gompel A, et al. (2000) Progestins were also proapoptotic in normal as well as in hormone-dependent breast cancer cells. Steroids 65(10-11):593-598.

7 Bu SZ ( 1997) Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines. Cancer 79(10):1944-50.

2.What plant does the progesterone used in Oasis Serene come from and what does USP mean?

Oasis Serene Natural Progesterone cream uses USP micronized progesterone derived from the wild yam plant. All USP progesterone creams are derived either from the soy plant or wild yam. Progesterone from soy and from wild yam produce the exact same quality of progesterone.

USP means United States Pharmaceutical grade which means that it is guaranteed to be extracted under the strictest of standards and the highest quality source of progesterone, plant-derived that is converted to human progesterone to identically match women's natural hormonal needs. Many companies on the internet claim their progesterone cream contains "real progesterone".  Checking the ingredient list reveals that they are using Wild Mexican Yam, or Mexican Wild Yam Root Extract, or "pharmaceutical quality" progesterone. These are all code words for the same product, Diosgenin. The human body does not produce the enzymes necessary to convert Diosgenin, the active component of Wild Mexican Yam, into progesterone. Clinical studies have shown beyond a doubt that Wild Mexican Yam or Diosgenin does not increase progesterone levels in the human body. Only USP progesterone is bio-identical in every respect to progesterone of the corpus luteum from female ovaries. Only USP natural progesterone will produce an increase in saliva and serum levels of progesterone. Companies use Diosgenin because it’s less than half the cost of USP progesterone. Diosgenin, by any name, is not progesterone; it won’t turn into progesterone in your body; it does not provide the benefits of progesterone.

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