Benefits of Lithium Orotate

July 11th, 2016 by Loretta Lanphier, NP, BCTN, CN, CH, HHP

Benefits of Lithium Orotate

What comes to mind when you hear the words prescription lithium? Most people either think “mental illness” or about family/friends who have experienced the often worrisome side effects of pharmaceutical lithium carbonate. We’ve all heard the phrase “the dose makes the poison” and with lithium this is definitely the case. Let’s take a look at low dose lithium and the researched benefits of lithium orotate – a lesser known product. You may be surprised.

What is Lithium?

Lithium is a trace mineral much like sodium and potassium. It is a natural occurring mineral salt that we all need for optimal mental and physical health and is not a drug. The FDA approved lithium as a treatment for bipolar disorder in 1970. Unfortunately, as soon as the FDA approves a natural occurring nutrient for the treatment of a disease or health issue, it is forever referred to as a drug.

Lithium is classified as an essential micro-nutrient, meaning that all humans require lithium in small doses for optimum health.

High dose lithium carbonate (pharmaceutical) can depress dopamine release which tends to flatten elevated moods, while at much lower amounts lithium orotate can stimulate serotonin synthesis giving an antidepressant effect. Lithium carbonate, typically prescribed for anxiety, bi-polar disorder, and other mental health issues, exposes patients to high dose lithium and is associated with many harmful side effects, especially to the liver. In fact, using prescription lithium requires checking blood levels regularly.

Lithium was the original “up” ingredient in 7-UP soda until 1950.
The drink, which contained the compound lithium citrate, started selling  just two weeks before the stock market crashed in October 1929, kicking off the Great Depression.

Using data from 1978-1987, Schrauzer and Shrestha published a paper called “Lithium in Drinking Water and the Incidences of Crimes, Suicides, and Arrests Related to Drug Addictions.” They took information about the lithium level in the water of 27 counties in Texas. The results showed that counties with higher lithium levels in the water had a statistically significant decrease in the incidence of homicide, suicide, arrests for opiates and cocaine, and violent criminal behavior. It’s important to know that “higher lithium levels” translates to about 2mg of lithium a day. Pharmacologic psychiatric doses typically start at 300mg daily.

According to the 1989 paper: “Lithium has previously been used to control episodic outbreaks of rage among prisoners and in the management of drug abusers.  Animal experiments have demonstrated that lithium suppresses cocaine-induced super sensitivity…the kindling phenomenon following the chronic application of…a central nervous system stimulant, and head-twitching in response to the administration of mescaline.  Furthermore, lithium has been found to [improve] distractibility… and produce improvement of selective attention to stimuli… it prevents behavioral alterations owing to social isolation, lowers [aggressive behavior] owing to confinement…and causes a normalization of spontaneous motor activity.


 What Are the Benefits of Lithium?

The benefits of lithium are many; in fact, lithium has been used as a mood stabilizer for decades. As said above, it’s usually in the form of lithium salts such as prescription high dose lithium carbonate or lithium citrate, but it’s also available in a non-prescription low-dose supplement form known as lithium orotate.

Clinical research tells us that the benefits of lithium are active in the following functions:

  • Protects brain cells from toxicity
  • Promotes brain cell regeneration
  • Increases gray matter of the brain
  • Regulates brain neurotransmitters
  • Supports healthy mood balance
  • Improves blood sugar metabolism
  • May increase telomeres and prolong lifespan

Other research also tells us lithium to be a key element in brain “healthy-aging” due to its ability to increase brain cell mass, which can also increase mental alertness and memory.

What are Orotates?

Orotates are defined as the mineral salts of orotic acid which is a natural substance found in the body and also in various foods including dairy products. Dr. Nieper, theorized many years ago that orotates are a component of a natural system of electrolyte carriers for distributing minerals throughout the body.

Based on Dr. Nieper’s observations of cells in culture, he concluded that molecules of calcium orotate and magnesium orotate can pass through cell membranes intact without “dissociating” or breaking apart into their component ions, and thereafter release their respective ions only at specific membrane sites within the cell. Subsequently Dr. Nieper extended this principle to include other orotates such as lithium orotate, potassium orotate and zinc orotate.

What is Lithium Orotate?

Lithium Orotate is the trace mineral lithium combined with orotic acid and was developed by the pioneering German physician, Dr. Hans Nieper. Dr. Nieper reported that just a small dose of 5 mg of elemental lithium in the form of orotate was roughly as effective as 100 mg of lithium in the form of carbonate, giving a 20-fold enhancement of potency thanks to efficient transport of the lithium by its orotate carrier.

Unlike its pharmaceutical counterparts, lithium orotate is non-toxic and is usually found effective for 70-80% of people who try it.

How Is Lithium Orotate Different From Prescription Lithium?

The most important difference between lithium orotate and lithium carbonate (prescription lithium) is how they are dosed. Lithium orotate contains about 4 mg of actual or elemental lithium per 100 mg dose. In contrast, lithium carbonate contains about 19 mg of lithium per 100 mg. This is almost five times more of lithium than lithium orotate.

Lithium orotate likely causes fewer side effects because it contains much less lithium than its prescription counterparts.

It’s also important to understand how both prescription lithium carbonate and lithium orotate are taken.

  • Lithium carbonate is usually prescribed at doses of 900-1800 mg/day. This gives a person about 170-340 mg of elemental lithium.
  • Lithium orotate usually contains only 5 mg of elemental lithium per dose.

Lithium Orotate has been shown to be three times more absorbed (more bioavailability) by brain cells. “…the 24 hour brain concentration of lithium after lithium orotate was approximately three times greater than that after lithium carbonate.” This allows for therapeutic servings of Lithium Orotate to be administered at least 1/3 of the amount of pharmaceutical lithium which brings the lithium levels down well below the toxic limits of lithium supplementation.

Benefits of Lithium Orotate

Health Benefits of Lithium Orotate

  1. Brain Protection – Research indicates the trace mineral lithium can support the grey matter nerve cells in the brain.
  2. Healthy-Aging Effects – Lithium Orotate in small amounts has been shown to offer healthy-aging effects to the brain.
  3. Neuroprotection from Environmental Toxins – Lithium has been shown to protect the system from numerous toxins, particularly in the grey matter of the brain.
  4. Lithium may promote autophagy – From a cellular perspective, autophagy is like a “detox”. Autophagy literally takes old cell material, recycles it, and re-uses the components. This process regenerates aging cells, deters diseases, and it’s a very important key to lifespan extension.
  5. May help improve sleep – Lithium can help lengthen the circadian rhythm period, which can help you if you are desynchronized from a normal 24-hour cycle.

Other Health Benefits of Lithium Orotate

  • Promotes normal white blood cell count
  • Supports liver health
  • Boosts general well-being
  • Encourages a healthy thyroid
  • Supports a healthy mental balance and a good mood
  • Supports healthy eye site
  • Supports healthy cortisol levels
  • Possible support for alcohol cravings

Lithium Safety

Based on research, Lithium carbonate (prescription lithium) should not be taken if you have Renal disease, have Cardiovascular disease, are severely ill, are pregnant, suffer from dehydration, take Diuretics, take ACE inhibitors, take beta-blockers or other anti-hypertension drugs, take insulin.

Although the warnings above appear to be true for pharmaceutical lithium compounds only and not for a modest serving of lithium orotate, it’s always wise to consult with a knowledgeable health care professional for anyone contemplating using lithium orotate concurrently with any medications.

If you are already taking prescription lithium you should not under any circumstances add lithium orotate to your regimen as you may already be at or near a toxic level of lithium within your bloodstream. And you should never stop taking prescription lithium without first consulting with your doctor.

In Conclusion…

Even though a recommended daily allowance (RDA) for lithium has never been established, a provisional RDA of 1 mg (milligram) daily for an adult weighing 70 kg (154 pounds) is established by most experts. It’s also important to note that the World Health Organization (WHO) in 1966 added lithium to its list of nutritionally essential trace elements, along with iodine, zinc, and other trace elements. Incorporating a bit more of this earth-sourced mineral may help in a better management of stress, a calming mood as well as support in boosting brain health and focus.

Taking low-dose supplemental amounts allow you to get the benefits of lithium orotate without the side effects that can come from taking higher doses. A Lithium Orotate supplement is a great way to integrate low-dose servings of lithium into your daily health routine.


  1. Schrauzer GN. Lithium: occurrence, dietary intakes, nutritional essentiality. The Journal of the American College of Nutrition. 2002 February;21(1):14-21.
  2. On the physiological function of lithium from a psychiatric view point. Med Hypotheses. 2001 Oct;57(4):506-9.
  3. Jakobsson E, Argüello-Miranda O, Chiu SW, et al. Towards a Unified Understanding of Lithium Action in Basic Biology and its Significance for Applied Biology. J Membr Biol. 2017;250(6):587–604. doi:10.1007/s00232-017-9998-2.
  4. Szklarska D, Rzymski P. Is Lithium a Micronutrient? From Biological Activity and Epidemiological Observation to Food Fortification. Biol Trace Elem Res. 2019;189(1):18–27. doi:10.1007/s12011-018-1455-2.
  5. Noguchi T, Lo K, Diemer T, Welsh DK. Lithium effects on circadian rhythms in fibroblasts and suprachiasmatic nucleus slices from Cry knockout mice. Neurosci Lett. 2016;619:49–53. doi:10.1016/j.neulet.2016.02.030.
  6. Monkul ES, Matsuo K, Nicoletti MA, Dierschke N, Hatch JP, Dalwani M, Brambilla P, Caetano S, Sassi RB, Mallinger AG, Soares JC. Prefrontal gray matter increases in healthy individuals after lithium treatment: a voxel-based morphometry study. Neuroscience Letters. 2007 December 11;429(1):7-11.
  7. Chuang DM. Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodenerative diseases? Critical Reviews in Neurobiology. 2004;16(1-2):83-90.
  8. Motoi Y, Shimada K, Ishiguro K, Hattori N. Lithium and autophagy. ACS Chem Neurosci. 2014;5(6):434–442. doi:10.1021/cn500056q.
  9. Zamani A, Omrani GR, Nasab MM. Lithium’s effect on bone mineral density. Bone. 2009 February;44(2):331-4. doi: 10.1016/j.bone.2008.10.001.
  10. Bolton JM, Metge C, Lix L, Prior H, Sareen J, Leslie WD. Fracture risk from psychotropic medications: a population-based analysis. Journal of Clinical Psychopharmacology. 2008 August;28(4):384-91. doi: 10.1097/JCP.0b013e31817d5943.
  11. Vestergaard P. Skeletal effects of central nervous system active drugs: anxiolytics, sedatives, antidepressants, lithium and neuroleptics. Current Drug Safety. 2008 September;3(3):185-9.
  12. Clément-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssiere B, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proceedings of the National Academy of Sciences U.S.A. 2005 November 29;102(48):17406-11.
  13. Maria Flavia Dorrego, Ph.D.; Lilia Canevara, M.D.; Gabriela Kuzis, Ph.D.; Liliana Sabe, Ph.D.; Sergio E. Starkstein, M.D., Ph.D. A Randomized, Double-Blind, Crossover Study of Methylphenidate and Lithium in Adults With Attention-Deficit/Hyperactivity Disorder: Preliminary Findings. The Journal of Neuropsychiatry and Clinical Neurosciences 2002;14:289-295.
  14. Erickson HM Jr, Goggin JE, Messiha FS. Comparison of lithium and haloperidol therapy in Gilles de la Tourette syndrome. Advances in Experimental Medicine and Biology. 1977;90:197-205.
  15. J Lieb. The anti-prostaglandin, immunostimulating and antimicrobial properties of lithium and antidepressants. Ecancermedicalscience. 2008; 2: 88.
  16. Szuster-Ciesielska A, Tustanowska-Stachura A, Slotwinska M, Marmurowska-Michalowska H, Kandefer-Szerszen M. In vitro immunoregulatory effects of antidepressants in healthy volunteers. Polish Journal of Pharmacology. 2003 May-Jun;55(3):353-62.
  17. Lieb J. Lithium and antidepressants: inhibiting eicosanoids, stimulating immunity, and defeating microorganisms. Medical Hypotheses. 2002 October;59(4):429-32.
  18. Zarse K, Terao T, Tian J, Iwata N, Ishii N, Ristow M. Low-dose lithium uptake promotes longevity in humans and metazoans. European Journal of Nutrition. 2011 August;50(5):387-9. doi: 10.1007/s00394-011-0171-x.
  19. de Vasconcellos AP, Nieto FB, Crema LM, Diehl LA, de Almeida LM, Prediger ME, da Rocha ER, Dalmaz C. Chronic lithium treatment has antioxidant properties but does not prevent oxidative damage induced by chronic variate stress. Neurochemical Research. 2006 September;31(9):1141-51.
  20. Rasmussen SA. Lithium and tryptophan aumentation in clomipramine-resistant obsessive-compulsive disorder. The American Journal of Psychiatry. 1984 October;141(10):1283-5.
  21. Pallanti S, Haznedar MM, Hollander E, Licalzi EM, Bernadi S, Newmark R, Buchsbaum MS. Basal Ganglia activity in pathological gambling: a fluorodeoxyglucose-positron emission tomography study. Neuropsychobiology. 2010;62(2):132-8. doi: 10.1159/000317286.
  22. Dziedzicka-Wasylewska M, Mackowiak M, Fijat K, Wedzony K. Adaptive changes in the rat dopaminergic transmission following repeated lithium administration. J Neural Transm Gen Sect. 1996;103(7):765-76.
  23. Perez-Cruet J, Tagliamonte A, Tagliamonte P, Gessa GL. Stimulation of serotonin synthesis by lithium. J Pharmacol Exp Ther. 1971;178(2):325-30.
  24. Nieper HA. Revolution in Technology, Medicine and Society. Oldenburg, Germany: MIT Verlag; 1985. Available from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
  25. Nieper HA. Recalcification of bone metastases by calcium diorotate. Agressologie. 1970;11(6):495-502. Available as article #CA21 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
  26. Nieper HA. The clinical applications of lithium orotate. A two years study. Agressologie. 1973;14(6):407-11. Available as article #CM12 from the A. Keith Brewer International Science Library at (608) 647-6513 or on the Web.
  27. Kling MA, Manowitz P, Pollack IW. Rat brain and serum lithium concentrations after acute injections of lithium carbonate and orotate. J Pharm Pharmacol. 1978 Jun;30(6):368-70.
  28. Schrauzer GN. Lithium: occurrence, dietary intakes, nutritional essentiality. J Am Coll Nutr. 2002 Feb;21(1):14-21.
  29. World Health Organization. Trace elements in human nutrition and health. 1996. Accessed 24 Dec 2018.
Loretta Lanphier is a Naturopathic Practitioner (Traditional), Certified Clinical Nutritionist, Holistic Health Practitioner and Certified Clinical Herbalist as well as the CEO / Founder of Oasis Advanced Wellness in The Woodlands TX. She studies and performs extensive research in health science, natural hormone balancing, anti-aging techniques, nutrition, natural medicine, weight loss, herbal remedies, non-toxic cancer support and is actively involved in researching new natural health protocols and products. A 19 year stage 3 colon cancer survivor, Loretta is able to relate to both-sides-of-the-health-coin as patient and practitioner when it comes to health and wellness. “My passion is counseling others about what it takes to keep the whole body healthy using natural and non-toxic methods.” Read Loretta’s health testimony Cancer: The Path to Healing. Loretta is Contributor and Editor of the worldwide E-newsletter Advanced Health & Wellness
†Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. Oasis Advanced Wellness/OAWHealth does not dispense medical advice, prescribe, or diagnose illness. The views and nutritional advice expressed by Oasis Advanced Wellness/OAWHealth are not intended to be a substitute for conventional medical service. If you have a severe medical condition or health concern, see your physician of choice.






You can use these tags: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

Join Thousands of People & Receive - Advanced Health & Wellness Monthly Newsletter
Join Our Wellness Newsletter!