Inflammation – Root Cause of Disease

February 27th, 2015 by Loretta Lanphier, NP, BCTN, CN, CH, HHP

Inflammation – Root Cause of Disease

Updated – March 2022

Medical science is undergoing a quiet revolution. Many alternative and natural health care practitioners have long understood the connection between disease and inflammation and the immune system’s role. However, the conventional medical establishment is beginning to rethink the whole matter. Certain illnesses, such as arthritis, have been widely accepted as “inflammatory diseases.” Still, more and more research is pointing towards the critical role that chronic inflammation plays in other health concerns such as heart disease, diabetes, and depression. Some researchers believe that inflammation is one of the major players in virtually all forms of disease.

What Is Inflammation?

Inflammation is a term that is no stranger to most people. It is associated with redness and tenderness in wounds and is a normal body response when there is tissue damage or infection. Inflammation is a function of the immune system that is part of how our amazing bodies seek to repair and heal themselves. However, when the inflammatory process is out of balance due to an immune system that is not functioning correctly, the chemical responses that trigger inflammation do not get turned off after the crisis is dealt with, and the result is chronic inflammation. The immune system remains on high alert, and it begins to get aggressive with healthy tissues, mistakenly viewing them as invaders to be attacked. This is known as autoimmune disease, and there has been a significant increase in the incidence of autoimmune diseases in recent decades.

There are many types of autoimmune diseases, and we are just beginning to understand in more detail how chronic inflammation and autoimmune disease are related. Many illnesses are autoimmune, including allergies, asthma, diabetes, and even conventional medicine recognizes the link between heart disease, atherosclerosis, stroke, and chronic inflammation. Inflammatory disease is at epidemic levels in the United States and other developed nations. Over 70 million Americans suffer from arthritis, close to 40 million have allergies, and about 17 million are asthmatic – not to mention the onslaught of coronary disease, the number one killer in the US. Let’s take a closer look at the specifics of inflammation related to the disease process and some possible reasons why inflammatory diseases are getting increasingly more common.

The Inflammation Process

A healthy immune system responds to wounds or infectious agents by sending out chemicals and specialist cells to protect and heal the body. This is a normal response that indicates an immune system that is strong and functional. Inflammatory or autoimmune diseases become a concern when the immune system crosses its signals and does not stop responding to the healing crisis – thus, inflammation continues. This is chronic inflammation, and when the immune system runs amok like this, it harms the body’s tissues and causes disease rather than preventing it.

With some conditions, such as rheumatoid arthritis, it is relatively simple to understand the harmful effects of inflammation. It has long been known that arthritis results from too much chronic inflammation of joints and connective tissues. But the vast news about inflammation is that it is now becoming clear that chronic inflammation may be one of the foundational principles behind most, if not all, diseases. Scientists are starting to connect the dots, and the evidence points to inflammation as the culprit behind conditions that, until now, were blamed on different factors. In a nutshell, any factors that “cause” an illness are, in reality, causing inflammation that triggers the symptom of that illness. And beyond that, even a bigger picture is beginning to unfold. It appears that chronic inflammation related to a disease in one part of the body does not tend to remain local but may make a person susceptible to other illnesses because of the common factor behind them all: chronic inflammation. Once inflammation gets a foothold in the body, it appears to alter the immune system so that systematic autoimmune diseases can spread and flourish.

Inflammation is a normal part of the body’s defense to injury or infection, and, in this way, it is beneficial. But inflammation is damaging when it occurs in healthy tissues or lasts too long. Known as Chronic Inflammation, it may persist for months or years.

Inflammation may result from many factors, such as:

  • Environmental chemicals
  • Injuries like scrapes, insect stings, or a splinter in your finger
  • Pathogens (germs) like bacteria, viruses, or fungi
  • Radiation

Inflammation plays a key role in many diseases, some of which are becoming more common and severe. Chronic inflammatory diseases contribute to more than half of deaths worldwide.

Chronic inflammation is associated with diseases such as the following:

  • Autoimmune diseases like rheumatoid arthritis
  • Cardiovascular diseases like high blood pressure and heart disease
  • Gastrointestinal disorders like inflammatory bowel disease
  • Lung diseases like asthma
  • Mental illnesses like depression
  • Metabolic diseases like Type 2 diabetes
  • Neurodegenerative diseases like Parkinson’s disease
  • Many types of cancer, like colon and breast cancer

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The Link Between Coronary Disease and Inflammation

The discovery of the chronic inflammation/autoimmune matrix has revolutionized medicine. Perhaps the best way to illustrate this is to discuss a specific illness, coronary disease–including atherosclerosis and stroke-and how our understanding of it has changed.

The standard approach to heart attacks, stroke, and atherosclerosis (hardening of the arteries) has typically been a circulatory disorder that occurs when arteries get clogged and interfere with the blood supply. Conventional medicine thought they had it all figured out when they identified certain factors that “cause” coronary disease, such as a high-fat diet, increased LDL cholesterol levels, obesity, a sedentary lifestyle, smoking, and others. These are certainly factors in heart disease, but what is coming to light is that they are factors that cause excessive inflammation. The inflammation is a common feature that links many diseases that were not thought to be related – until now. One researcher stated that his understanding of this common link has totally changed the way he educates others. He often gives lectures, and he has taken to using many of the same slides to illustrate disease, whether he is discussing illnesses of the heart, lungs, kidneys, or other tissues. Since they are all a function of chronic inflammation, the similarities between many diseases are astounding.

Let’s get back to coronary disease. Not only has the “inflammation factor” affected what we thought we already knew about heart disease, but it has also expanded our understanding. For example, when inflammation is in the equation, it appears that atherosclerosis becomes more than simply a “plumbing concern” regarding clogged arteries. In addition, research indicates that LDL gets embedded into the artery walls, and the immune system then targets it as an invader, and the inflammation further damages the arteries and compounds the concern. Before this discovery, the immune system and inflammation were never linked to heart disease. This major breakthrough is causing scientists to take another long look at everything they “know” about disease. Perhaps the key to curing and preventing many diseases, such as cancer, diabetes, and a slew of other illnesses, is to target inflammation.

Before we leave the topic of heart disease, let me discuss an important indicator that makes all of the above more than just theory. What if there were a test that could indicate the inflammation in the body. Could this information be used to treat and predict heart disease, and ultimately other diseases as well? Well, there is a test, and it is thought, even by conventional medicine, that it is very useful at prediction and prevention.

C-reactive protein (CRP) is a protein that is produced as a byproduct of inflammation, and levels of CRP can be measured in the blood, indicating the overall inflammation in the body. Studies have been done specifically on the relationship between cardiovascular disease and levels of CRP, and a test called the highly-sensitive C-reactive protein assay (hs-CRP) has been developed. This assay is being used by mainstream medical cardiologists to predict the overall risk for heart disease, the risk of first-time cardiovascular events such as heart attack and stroke, and the likelihood of recurrent occurrences of such events in folks who have a history of them.

Hs-CRP is a relatively inexpensive test that will run you about $30, give or take if you don’t have insurance to cover it. Unless you are at the peak of health and are very disciplined in your diet and lifestyle, I would recommend that you request this test to get an idea of the inflammation in your body. hs-CRP results are rated as follows:

  • Less than 1.0 mg/L is considered a low risk for cardiovascular disease.
  • Between 1.0 and 3.0 mg/L is the average risk.
  • Greater than 3.0 mg/L is high risk.

The fascinating thing is that CRP is only one of multiple inflammation indicators, and as we learn more we may be able to link other indicators with specific diseases. But even knowledge of overall levels of inflammation is beneficial. The next logical question is: what causes inflammation, and how can I prevent it?

Depression – An Allergic Reaction to Inflammation

A recent study indicates that an allergic reaction from inflammation can cause depression. Health Science and the Human Brain (January 6, 2015) noted the new research reveals an allergic reaction from inflammation causes many cases of depression. Tim de Chant of NOVA wrInflammationmmation is our immune system’s natural response to injuries, infections, or foreign compounds. When triggered, the body pumps various cells and proteins to the site through the bloodstream, including cytokines, a class of proteins that facilitate intercellular communication. It also happens that people suffering from depression are loaded with cytokines.”

By treating the inflammatory symptoms of depression — rather than the neurological ones — researchers and doctors are opening up an exciting new dimension in the fight against what has become a global epidemic. There is evidence that omega-three fatty acids and curcumin, an extract of the spice turmeric, might have similar effects as anti-inflammatory drugs. Other foods that help inflammation are ginger root, dark red cherries, blueberries, and hibiscus tea fight inflammation.

There is most definitely a connection between food and mood. Sugar is one of the leading causes of the blues. Ever since the get-rid-of-all-fat craze, we’ve been dumping sugar in just about everything. The result is that depression rates are rising, as well as diabetes, heart disease, and cancer.

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Common Causes of Chronic Inflammation

  • Obesity: Fat cells were once thought to be neutral “storage units,” but we now know that fat deposits, especially in the abdominal region, are triggers for-you guessed it-inflammation.
  • Poor digestive health: As the saying goes, “Health begins in the gut.” A poor diet and unbalanced levels of healthy flora can trigger many illnesses, including leaky gut syndrome, colitis, Crohn’s disease, and other digestive disorders. But what these autoimmune diseases all have in common is that they are the result of inflammation in the intestinal tract. Our modern diets, typically high in fat and low in fiber and antioxidants cause inflammation – the key to both wellness and disease is found in the gut.
  • Hyperglycemia: Excessive blood sugar levels are linked to diabetes and other disorders for years, but the real reason is that too much sugar, especially refined sugars, increases insulin in the blood, which sets off an immune response that ultimately leads to inflammation.
  • Environmental toxins: Exposure to pesticides, heavy metals, chemicals, and other pollutants has been identified as a trigger for inflammation as well. Autoimmune disorders are linked to environmental factors, and the actual reason behind these diseases is that foundational principle that keeps showing its ugly head: inflammation.
  • Stress: Researchers from Ohio State University, the University of California, Los Angeles, Northwestern University, and the University of British Columbia found that chronic stress changes gene activity of immune cells before they enter the bloodstream so that they’re ready to fight infection or trauma — even when there is no infection or trauma to fight – leading to inflammation.

How to Reduce Inflammation Naturally

The best way to minimize disease in your life is to pursue wellness with a lifestyle of healthy eating, exercise, and avoidance of known toxins. A healthy diet is crucial, and some foods identify as both lowering and raising inflammation levels.

  • Veggies & Fruit. Load up on lots of fresh organic fruits and vegetables. These foods high in antioxidants are anti-inflammatory, and they will get right to the root of the issue by keeping you well so that you don’t have to fight off sickness and develop inflammation.
  • Eliminate These foods. Eliminate processed and pre-packaged foods and foods laced with sugar, unhealthy fats, and chemical preservatives. These substances cause inflammation and lead you to obesity, which is a factor in inflammation.
  • Lose Weight. Fat deposits, especially when located in the abdominal region, are triggers for – you guessed it – inflammation.
  • EFAs are Essential. Essential Fatty Acids (EFAs) from Flax Seed Oil, Black Seed Oil, Hemp Seed Oil, and Unrefined Coconut Oil is encouraged.
  • Hydration. Drink at least 1/2 of your body weight in ounces of purified water every day. This will bathe your cells and also provide hydration to tissues and muscles. Adding one capful of organic, raw apple cider vinegar to each 16-ounce glass of pure water will also help with pain and inflammation.
  • Raw, Organic Apple Cider Vinegar.
  • Univase Forte Proteolytic Enzymes – 20% more potent than Wobenzyme, Univase Forte Proteolytic Enzyme formula contains ten different enzymes and other synergistic nutrients to enhance nutritional benefits and support the body’s natural inflammation response.
  • Digestive Enzymes. Breaking food down properly in the digestive tract can ease much of the inflammation that results when the body attempts to process poorly digested foods. In turn, the anti-inflammatory action of systemic enzymes can further aid in easing inflammation.
  • Probiotics and Prebiotics
  • Immune Boosting Oregano Oil
  • Liver & Gallbladder Cleansing
  • Chemical and Heavy Metal Cleansing
  • Other Natural Remedies for Inflammation: Bromelain, Astaxanthin, Organic Turmeric, Devil’s Claw, White Willow Bark, Cat’s Claw-TOA free, Eucommia (if you have high blood pressure consult with a practitioner first), Green Tea, Pycnogenol, Boswellia Serrata Resin (Frankincense), Resveratrol, Capsaicin.
  • Daily Exercise for Lymphatic Drainage. As with most things, moderation is key. I highly suggest walking, rebounding, working with weights, dry body brushing, and stationary bikes.
  • Restful Sleep. Most experts recommend sleeping for six to eight hours nightly to ensure restful sleep. Try to go to bed at the same time every night, including weekends.

We have only begun to scratch the surface when it comes to understanding inflammation in disease. It will be fascinating to watch as our knowledge increases and see how much of a difference this makes in our pursuit of health and avoidance of sickness. Inflammation may well be the buzzword regarding wholeness and good health for many years to come.

Research and More Information

Andrew S Greenberg, Martin S Obin. Obesity and the role of adipose inflammation and metabolism. The American Journal of Clinical Nutrition. February 2006 vol. 83 no.2 pages 461S-465S.

Proc Natl Acad Sci. Published online October 20, 2014. Abstract

Joseph C. Maroon, Jeffrey W. Bost, Adara Maroon. Natural anti-inflammatory agents for pain relief. Surg Neurol Int. 2010; 1: 80. Published online 2010 December 13. DOI: 10.4103/2152-7806.73804. PMCID: PMC3011108
Loretta Lanphier is a NaturopathPractitioner, Board Certified Traditional Naturopath, Certified Clinical Nutritionist, Holistic Health Practitioner, and Certified Clinical Herbalist as well as the CEO / Founder of Oasis Advanced Wellness in The Woodlands TX. She studies and performs extensive research in health science, natural hormone balancing, anti-aging techniques, nutrition, natural medicine, weight loss, herbal remedies, non-toxic cancer support. She is actively involved in researching new natural health protocols and products. A 21-year stage 3 colon cancer survivor, Loretta can relate to both-sides-of-the-health-coin as patient and practitioner regarding health and wellness. “My passion is counseling others about what it takes to keep the whole body healthy using natural and non-toxic methods.” Read Loretta’s health testimony Cancer: The Path to Healing. Loretta is a Contributor and Editor of the worldwide E-newsletter Advanced Health & Wellness
†Results may vary. Information and statements made are for education purposes and are not intended to replace the advice of your doctor. Oasis Advanced Wellness/OAWHealth does not dispense medical advice, prescribe, or diagnose illness. The views and nutritional advice expressed by Oasis Advanced Wellness/OAWHealth are not intended to be a substitute for conventional medical service. If you have a severe medical condition or health concern, see your physician of choice.








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